Functional genomics identifies predictive markers and clinically actionable resistance mechanisms to CDK4/6 inhibition in bladder cancer

BACKGROUND: CDK4/6 inhibitors are a promising treatment strategy in tumor therapy but are hampered by resistance mechanisms. This study was performed to reveal predictive markers, mechanisms of resistance and to develop rational combination therapies for a personalized therapy approach in bladder ca...

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Detalles Bibliográficos
Autores principales: Tong, Zhichao, Sathe, Anuja, Ebner, Benedikt, Qi, Pan, Veltkamp, Christian, Gschwend, Juergen E., Holm, Per Sonne, Nawroth, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647307/
https://www.ncbi.nlm.nih.gov/pubmed/31331377
http://dx.doi.org/10.1186/s13046-019-1322-9

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