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Fugitives on the run: circulating tumor cells (CTCs) in metastatic diseases

The presence of circulating tumor cells (CTCs) in the bloodstream signals the existence of a tumor and denotes risk of metastatic spread. CTCs can be isolated and analyzed to monitor cancer progression and therapeutic response. However, CTC isolation devices have shown considerable variation in dete...

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Autores principales: Mamdouhi, Tania, Twomey, Julianne D., McSweeney, K. Melodi, Zhang, Baolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647404/
https://www.ncbi.nlm.nih.gov/pubmed/31053984
http://dx.doi.org/10.1007/s10555-019-09795-4
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author Mamdouhi, Tania
Twomey, Julianne D.
McSweeney, K. Melodi
Zhang, Baolin
author_facet Mamdouhi, Tania
Twomey, Julianne D.
McSweeney, K. Melodi
Zhang, Baolin
author_sort Mamdouhi, Tania
collection PubMed
description The presence of circulating tumor cells (CTCs) in the bloodstream signals the existence of a tumor and denotes risk of metastatic spread. CTCs can be isolated and analyzed to monitor cancer progression and therapeutic response. However, CTC isolation devices have shown considerable variation in detection rates, limiting their use as a routine diagnostic and monitoring tool. In this review, we discuss recent advances in CTC detection methodologies and associated clinical studies. We provide perspective on the future direction of CTC isolation and molecular characterization towards developing reliable biomarkers that monitor disease progression or therapeutic response.
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spelling pubmed-66474042019-08-06 Fugitives on the run: circulating tumor cells (CTCs) in metastatic diseases Mamdouhi, Tania Twomey, Julianne D. McSweeney, K. Melodi Zhang, Baolin Cancer Metastasis Rev Non-Thematic Review The presence of circulating tumor cells (CTCs) in the bloodstream signals the existence of a tumor and denotes risk of metastatic spread. CTCs can be isolated and analyzed to monitor cancer progression and therapeutic response. However, CTC isolation devices have shown considerable variation in detection rates, limiting their use as a routine diagnostic and monitoring tool. In this review, we discuss recent advances in CTC detection methodologies and associated clinical studies. We provide perspective on the future direction of CTC isolation and molecular characterization towards developing reliable biomarkers that monitor disease progression or therapeutic response. Springer US 2019-05-03 2019 /pmc/articles/PMC6647404/ /pubmed/31053984 http://dx.doi.org/10.1007/s10555-019-09795-4 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Non-Thematic Review
Mamdouhi, Tania
Twomey, Julianne D.
McSweeney, K. Melodi
Zhang, Baolin
Fugitives on the run: circulating tumor cells (CTCs) in metastatic diseases
title Fugitives on the run: circulating tumor cells (CTCs) in metastatic diseases
title_full Fugitives on the run: circulating tumor cells (CTCs) in metastatic diseases
title_fullStr Fugitives on the run: circulating tumor cells (CTCs) in metastatic diseases
title_full_unstemmed Fugitives on the run: circulating tumor cells (CTCs) in metastatic diseases
title_short Fugitives on the run: circulating tumor cells (CTCs) in metastatic diseases
title_sort fugitives on the run: circulating tumor cells (ctcs) in metastatic diseases
topic Non-Thematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647404/
https://www.ncbi.nlm.nih.gov/pubmed/31053984
http://dx.doi.org/10.1007/s10555-019-09795-4
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