Development and validation of a bioanalytical method for the quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib in human and mouse matrices using liquid chromatography-tandem mass spectrometry

A novel method was developed and validated for the quantification of the three approved CDK4/6 inhibitors (abemaciclib, palbociclib, and ribociclib) in both human and mouse plasma and mouse tissue homogenates (liver, kidney, spleen, brain, and small intestine) using liquid chromatography coupled to...

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Detalles Bibliográficos
Autores principales: Martínez-Chávez, Alejandra, Rosing, Hilde, Hillebrand, Michel, Tibben, Matthijs, Schinkel, Alfred H., Beijnen, Jos H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647725/
https://www.ncbi.nlm.nih.gov/pubmed/31209549
http://dx.doi.org/10.1007/s00216-019-01932-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647725/
https://www.ncbi.nlm.nih.gov/pubmed/31209549
http://dx.doi.org/10.1007/s00216-019-01932-w

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