Cargando…

Quinazolinone Synthesis through Base-Promoted S(N)Ar Reaction of ortho-Fluorobenzamides with Amides Followed by Cyclization

[Image: see text] A transition-metal-free synthesis of quinazolin-4-ones by Cs(2)CO(3)-promoted S(N)Ar reaction of ortho-fluorobenzamides with amides followed by cyclization in dimethyl sulfoxide has been developed. The present procedure can provide efficient synthetic methods for the formation of b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iqbal, Muhammad Asif, Lu, Le, Mehmood, Hina, Khan, Dost Muhammad, Hua, Ruimao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647956/ https://www.ncbi.nlm.nih.gov/pubmed/31459909 http://dx.doi.org/10.1021/acsomega.9b00699

Ejemplares similares

Base-Promoted S(N)Ar Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles
por: Iqbal, Muhammad Asif, et al.
Publicado: (2019)

Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides
por: Iqbal, Muhammad Asif, et al.
Publicado: (2021)

Crystal structure and Hirshfeld surface analysis of N-(2-chlorophenylcarbamothioyl)-4-fluorobenzamide and N-(4-bromophenylcarbamothioyl)-4-fluorobenzamide
por: Akhter, Sidra, et al.
Publicado: (2019)

Enantioselective Copper‐Catalyzed Borylative Cyclization for the Synthesis of Quinazolinones
por: Dherbassy, Quentin, et al.
Publicado: (2021)

Base-Promoted One-Pot Synthesis of Pyridine Derivatives via Aromatic Alkyne Annulation Using Benzamides as Nitrogen Source
por: Mehmood, Hina, et al.
Publicado: (2021)

Base-Promoted Annulation of Amidoximes with Alkynes: Simple Access to 2,4-Disubstituted Imidazoles
por: Mehmood, Hina, et al.
Publicado: (2020)

N-Cyclohexyl-2-fluorobenzamide
por: Saeed, Aamer, et al.
Publicado: (2008)

N-Cyclohexyl-3-fluorobenzamide
por: Saeed, Aamer, et al.
Publicado: (2008)

Cyclization vs. Cyclization/Dimerization in o-Amidostilbene Radical Cation Cascade Reactions: The Amide Question
por: Kee, Chin Hui, et al.
Publicado: (2011)

Synthesis of Novel Heterocycles by Amide Activation and Umpolung Cyclization
por: Zhang, Haoqi, et al.
Publicado: (2020)

A Simple Metal-Free Cyclization for the Synthesis of 4-Methylene-3-Substituted Quinazolinone and Quinazolinthione Derivatives: Experiment and Theory
por: Yan, Huihui, et al.
Publicado: (2019)

Palladium(II) Catalyzed Cyclization-Carbonylation-Cyclization Coupling Reaction of (ortho-Alkynyl Phenyl) (Methoxymethyl) Sulfides Using Molecular Oxygen as the Terminal Oxidant
por: Shen, Rong, et al.
Publicado: (2016)

Unexpected cyclization of ortho-nitrochalcones into 2-alkylideneindolin-3-ones
por: Aksenov, Nicolai A., et al.
Publicado: (2020)

Stereoselective Synthesis of Atropisomeric Acridinium Salts by the Catalyst‐Controlled Cyclization of ortho‐Quinone Methide Iminiums
por: Wu, Xingxing, et al.
Publicado: (2022)

Visible Light Promotes Cascade Trifluoromethylation/Cyclization, Leading to Trifluoromethylated Polycyclic Quinazolinones, Benzimidazoles and Indoles
por: Ma, Ransong, et al.
Publicado: (2022)

Crystal structures of three N-(arylsulfonyl)-4-fluorobenzamides
por: Suchetan, P. A., et al.
Publicado: (2016)

Oxidative Cyclization at ortho-Position of Phenol: Improved Total Synthesis of 3-(Phenethylamino)demethyl(oxy)aaptamine
por: Nakatani, Yuki, et al.
Publicado: (2023)

Synthesis of 4H‐Benzo[e][1,3]oxazin‐4‐ones by a Carbonylation–Cyclization Domino Reaction of ortho‐Halophenols and Cyanamide
por: Åkerbladh, Linda, et al.
Publicado: (2017)

Synthesis of 4H‐Benzo[e][1,3]oxazin‐4‐ones by a Carbonylation–Cyclization Domino Reaction of ortho‐Halophenols and Cyanamide
por: Åkerbladh, Linda, et al.
Publicado: (2017)

Synthesis of P-Stereogenic Benzoazaphosphole 1-Oxides via Alkynylation of P-Stereogenic ortho-Aurated and ortho-Iodo Phosphinic Amides
por: Soengas, Raquel, et al.
Publicado: (2018)

TMSBr-Promoted Cascade Cyclization of ortho-Propynol Phenyl Azides for the Synthesis of 4-Bromo Quinolines and Its Applications
por: Jin, Fengyan, et al.
Publicado: (2019)

Gold-catalyzed tandem reactions of amide–aldehyde–alkyne coupling and cyclization-synthesis of 2,4,5-trisubstituted oxazoles
por: Querard, Pierre, et al.
Publicado: (2015)

Cyclization of ortho-hydroxycinnamates to coumarins under mild conditions: A nucleophilic organocatalysis approach
por: Boeck, Florian, et al.
Publicado: (2012)

Enantioselective Catalytic [4+1]‐Cyclization of ortho‐Hydroxy‐para‐Quinone Methides with Allenoates
por: Zielke, Katharina, et al.
Publicado: (2019)

Microwave-Assisted Synthesis of Quinazolines and Quinazolinones: An Overview
por: Mohammadkhani, Leyla, et al.
Publicado: (2020)

Recent advances and prospects in the organocatalytic synthesis of quinazolinones
por: Borah, Biplob, et al.
Publicado: (2022)

A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of4(3H)-Quinazolinones
por: Ighilahriz, Karima, et al.
Publicado: (2008)

Electro-oxidative cyclization: access to quinazolinones via K(2)S(2)O(8) without transition metal catalyst and base
por: Hu, Yongzhi, et al.
Publicado: (2021)

Further Studies on the Pyrolytic Domino Cyclization of Stabilized Phosphonium Ylides Bearing an Ortho-Aminophenyl Group
por: Aitken, R. Alan, et al.
Publicado: (2018)

Uses of 2-Ethoxy-4(3H) quinazolinone in Synthesis of Quinazoline and Quinazolinone Derivatives of Antimicrobial Activity: The Solvent Effect
por: El-Hashash, Maher A., et al.
Publicado: (2012)

Synthesis and anticancer activity of novel quinazolinone-based rhodanines
por: El-Sayed, Sherihan, et al.
Publicado: (2017)

A Bifurcated Multicomponent Synthesis Approach to Polycyclic Quinazolinones
por: Xu, Ruixue, et al.
Publicado: (2022)

Synthesis of Novel Quinazolinone Analogues for Quorum Sensing Inhibition
por: Shandil, Sahil, et al.
Publicado: (2023)

N-[Ethyl(2-hydroxyethyl)carbamothioyl]-3-fluorobenzamide
por: Awang, Nor Wahida., et al.
Publicado: (2014)

Dipolar Cycloaddition Reactions with Quinazolinones: A New Route for the Synthesis of Several Annelated Pyrrolo- and Pyridazinoquinazoline Derivatives
por: Ghabrial, Sami S., et al.
Publicado: (2003)

Chemical Characteristics, Synthetic Methods, and Biological Potential of Quinazoline and Quinazolinone Derivatives
por: Asif, Mohammad
Publicado: (2014)

Synthesis of Some New Quinazolinone Derivatives and Evaluation of Their Antimicrobial Activities
por: Khodarahmi, Ghadamali, et al.
Publicado: (2012)

Synthesis, Characterization, and Anti-Inflammatory Activity of Newer Quinazolinone Analogs
por: Rajput, Chatrasal Singh, et al.
Publicado: (2013)

“On-Water” Synthesis of Quinazolinones and Dihydroquinazolinones Starting from o-Bromobenzonitrile
por: Liu, Zibin, et al.
Publicado: (2018)

New Isoxazolidine-Conjugates of Quinazolinones—Synthesis, Antiviral and Cytostatic Activity
por: Piotrowska, Dorota G., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1eco3vvvvki0if5q55rgvov490