Catalyst-Free Approach for Hydroboration of Carboxylic Acids under Mild Conditions

[Image: see text] Herein, we present a facile method for deoxygenative hydroboration of a broad range of carboxylic acids under very mild conditions. The most striking feature of this attractive hydroboration is that this elusive and challenging transformation was realized without catalyst and solve...

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Autores principales: Xu, Xiaojuan, Yan, Dandan, Zhu, Zhangye, Kang, Zihan, Yao, Yingming, Shen, Qi, Xue, Mingqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647974/
https://www.ncbi.nlm.nih.gov/pubmed/31459799
http://dx.doi.org/10.1021/acsomega.9b00406
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author Xu, Xiaojuan
Yan, Dandan
Zhu, Zhangye
Kang, Zihan
Yao, Yingming
Shen, Qi
Xue, Mingqiang
author_facet Xu, Xiaojuan
Yan, Dandan
Zhu, Zhangye
Kang, Zihan
Yao, Yingming
Shen, Qi
Xue, Mingqiang
author_sort Xu, Xiaojuan
collection PubMed
description [Image: see text] Herein, we present a facile method for deoxygenative hydroboration of a broad range of carboxylic acids under very mild conditions. The most striking feature of this attractive hydroboration is that this elusive and challenging transformation was realized without catalyst and solvent. The investigation of solvent effect showed that tetrahydrofuran was also suitable for this kind of reaction. Moreover, a successful gram-scale trial may provide a very promising toolkit for carboxylic acid reduction at a large scale.
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spelling pubmed-66479742019-08-27 Catalyst-Free Approach for Hydroboration of Carboxylic Acids under Mild Conditions Xu, Xiaojuan Yan, Dandan Zhu, Zhangye Kang, Zihan Yao, Yingming Shen, Qi Xue, Mingqiang ACS Omega [Image: see text] Herein, we present a facile method for deoxygenative hydroboration of a broad range of carboxylic acids under very mild conditions. The most striking feature of this attractive hydroboration is that this elusive and challenging transformation was realized without catalyst and solvent. The investigation of solvent effect showed that tetrahydrofuran was also suitable for this kind of reaction. Moreover, a successful gram-scale trial may provide a very promising toolkit for carboxylic acid reduction at a large scale. American Chemical Society 2019-04-15 /pmc/articles/PMC6647974/ /pubmed/31459799 http://dx.doi.org/10.1021/acsomega.9b00406 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Xu, Xiaojuan
Yan, Dandan
Zhu, Zhangye
Kang, Zihan
Yao, Yingming
Shen, Qi
Xue, Mingqiang
Catalyst-Free Approach for Hydroboration of Carboxylic Acids under Mild Conditions
title Catalyst-Free Approach for Hydroboration of Carboxylic Acids under Mild Conditions
title_full Catalyst-Free Approach for Hydroboration of Carboxylic Acids under Mild Conditions
title_fullStr Catalyst-Free Approach for Hydroboration of Carboxylic Acids under Mild Conditions
title_full_unstemmed Catalyst-Free Approach for Hydroboration of Carboxylic Acids under Mild Conditions
title_short Catalyst-Free Approach for Hydroboration of Carboxylic Acids under Mild Conditions
title_sort catalyst-free approach for hydroboration of carboxylic acids under mild conditions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647974/
https://www.ncbi.nlm.nih.gov/pubmed/31459799
http://dx.doi.org/10.1021/acsomega.9b00406
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