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Optimized Stepwise Synthesis of the API Liraglutide Using BAL Resin and Pseudoprolines

[Image: see text] The number of peptide-based active pharmaceutical ingredients (APIs) has increased enormously in recent years. Furthermore, the emerging new peptide drug candidates are more complex and larger. For the industrial solid-phase synthesis of C-carboxylic acid peptides, the two main res...

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Detalles Bibliográficos
Autores principales: Carbajo, Daniel, El-Faham, Ayman, Royo, Miriam, Albericio, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648002/
https://www.ncbi.nlm.nih.gov/pubmed/31459957
http://dx.doi.org/10.1021/acsomega.9b00974