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Metabolites of Vinca Alkaloid Vinblastine: Tubulin Binding and Activation of Nausea-Associated Receptors

[Image: see text] Vinblastine (VLB) is an antimitotic drug that binds to the vinca site of tubulin. The molecule possesses a high molecular weight and a complex chemical structure with many possibilities of metabolization. Despite advances in drug discovery research in reducing drug toxicity, the ca...

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Detalles Bibliográficos
Autores principales:	Chagas, Caroline Manto, Alisaraie, Laleh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648052/ https://www.ncbi.nlm.nih.gov/pubmed/31460070 http://dx.doi.org/10.1021/acsomega.9b00652

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