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Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity

[Image: see text] To address an important challenge in the engineering of antioxidant nanoparticles, the present work devised a surface-to-bulk migration of oxygen vacancies in the oxygen radical-scavenging cerium-oxide nanoparticles. The study highlights the significance of surface oxygen vacancies...

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Autores principales: Gunawan, Cindy, Lord, Megan S., Lovell, Emma, Wong, Roong Jien, Jung, Moon Sun, Oscar, Diana, Mann, Riti, Amal, Rose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648134/
https://www.ncbi.nlm.nih.gov/pubmed/31460038
http://dx.doi.org/10.1021/acsomega.9b00521
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author Gunawan, Cindy
Lord, Megan S.
Lovell, Emma
Wong, Roong Jien
Jung, Moon Sun
Oscar, Diana
Mann, Riti
Amal, Rose
author_facet Gunawan, Cindy
Lord, Megan S.
Lovell, Emma
Wong, Roong Jien
Jung, Moon Sun
Oscar, Diana
Mann, Riti
Amal, Rose
author_sort Gunawan, Cindy
collection PubMed
description [Image: see text] To address an important challenge in the engineering of antioxidant nanoparticles, the present work devised a surface-to-bulk migration of oxygen vacancies in the oxygen radical-scavenging cerium-oxide nanoparticles. The study highlights the significance of surface oxygen vacancies in the intended cellular internalization and, subsequently, the radical scavenging activity of the nanoparticles inside the cells. The findings advise future development of therapeutic antioxidant nanomaterials to also include engineering of the particles for enhanced surface defects not only for the accessibility of their oxygen vacancies but also, equally important, rendering them bioavailable for cellular uptake.
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spelling pubmed-66481342019-08-27 Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity Gunawan, Cindy Lord, Megan S. Lovell, Emma Wong, Roong Jien Jung, Moon Sun Oscar, Diana Mann, Riti Amal, Rose ACS Omega [Image: see text] To address an important challenge in the engineering of antioxidant nanoparticles, the present work devised a surface-to-bulk migration of oxygen vacancies in the oxygen radical-scavenging cerium-oxide nanoparticles. The study highlights the significance of surface oxygen vacancies in the intended cellular internalization and, subsequently, the radical scavenging activity of the nanoparticles inside the cells. The findings advise future development of therapeutic antioxidant nanomaterials to also include engineering of the particles for enhanced surface defects not only for the accessibility of their oxygen vacancies but also, equally important, rendering them bioavailable for cellular uptake. American Chemical Society 2019-05-30 /pmc/articles/PMC6648134/ /pubmed/31460038 http://dx.doi.org/10.1021/acsomega.9b00521 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Gunawan, Cindy
Lord, Megan S.
Lovell, Emma
Wong, Roong Jien
Jung, Moon Sun
Oscar, Diana
Mann, Riti
Amal, Rose
Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity
title Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity
title_full Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity
title_fullStr Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity
title_full_unstemmed Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity
title_short Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity
title_sort oxygen-vacancy engineering of cerium-oxide nanoparticles for antioxidant activity
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648134/
https://www.ncbi.nlm.nih.gov/pubmed/31460038
http://dx.doi.org/10.1021/acsomega.9b00521
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