Cargando…

4,6-Dihydroxysalicylic Acid-Catalyzed Oxidative Condensation of Benzylic Amines and Aromatic Ketones for the Preparation of 2,4,6-Trisubstituted Pyridines and Its Application to Metal-Free Synthesis of G-Quadruplex Binding Ligands

[Image: see text] 4,6-Dihydroxysalicylic acid was activated under air to catalyze the one-pot oxidative condensation reaction of benzylamines with acetophenones in the presence of BF(3)·Et(2)O, affording 2,4,6-trisubstituted pyridines in yields of 59–91%. During this metal-free oxidative condensatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Chun-ping, Kodama, Shintaro, Nomoto, Akihiro, Ueshima, Michio, Ogawa, Akiya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648211/ https://www.ncbi.nlm.nih.gov/pubmed/31459991 http://dx.doi.org/10.1021/acsomega.9b00999

Ejemplares similares

An Orthogonal Synthetic Approach to Nonsymmetrical Bisazolyl 2,4,6-Trisubstituted Pyridines
por: Gamonal Ruiz-Crespo, Arturo, et al.
Publicado: (2022)

Cannabinoid Receptor 2 Signalling Bias Elicited by 2,4,6-Trisubstituted 1,3,5-Triazines
por: Oyagawa, Caitlin R. M., et al.
Publicado: (2018)

(E)-N′-(2,4,6-Trimethylbenzylidene)isonicotinohydrazide
por: Naveenkumar, H. S., et al.
Publicado: (2010)

Erratum: Cannabinoid Receptor 2 Signalling Bias Elicited by 2,4,6-Trisubstituted 1,3,5-Triazines
Publicado: (2019)

(E)-4-Chloro-N-(2,4,6-trimethylbenzylidene)aniline
por: Guo, Ying, et al.
Publicado: (2011)

Facile Synthesis, Characterization, and In Vitro Antimicrobial Screening of a New Series of 2,4,6-Trisubstituted-s-triazine Based Compounds
por: Singh, Ravi Bhushan, et al.
Publicado: (2015)

Efficient Synthesis of Amine-Linked 2,4,6-Trisubstituted Pyrimidines as a New Class of Bacterial FtsZ Inhibitors
por: Chan, Kin-Fai, et al.
Publicado: (2017)

Synthesis and PI 3-Kinase Inhibition Activity of Some Novel 2,4,6-Trisubstituted 1,3,5-Triazines
por: Nelson, Ronald A., et al.
Publicado: (2018)

(E)-N′-(2,4,6-Trihydroxybenzylidene)isonicotinohydrazide sesquihydrate
por: Naveenkumar, H. S., et al.
Publicado: (2010)

trans-Bis[8-(benzylsulfanyl)quinoline-κ(2) N,S]dichloridocobalt(II)
por: Kodama, Shintaro, et al.
Publicado: (2021)

1,2,3,3′,4′,6′-Hexaacetyl-4,6-O-benzylidenesucrose
por: Brito-Arias, Marco A., et al.
Publicado: (2011)

Benzyltributylammonium 4,6-dihydroxynaphthalene-2-sulfonate
por: Uta, Kazuya, et al.
Publicado: (2009)

Tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP): Efficient Catalysts for the Cyanosilylation and Cyanocarbonation of Aldehydes and Ketones
por: Matsukawa, Satoru, et al.
Publicado: (2009)

2,4,6-Trimethyl-3,5-bis[(phenylcarbonothioyl)sulfanylmethyl]benzyl benzenecarbodithioate
por: Kannan, M., et al.
Publicado: (2010)

(E)-2-[(2,4,6-Trimethoxybenzylidene)amino]phenol
por: Kaewmanee, Narissara, et al.
Publicado: (2013)

Tris(4,4′-di-tert-butyl-2,2′-bipyridine)(trans-4-tert-butylcyclohexanolato)deca-μ-oxido-heptaoxidoheptavanadium acetonitrile monosolvate including another unknown solvent molecule
por: Kodama, Shintaro, et al.
Publicado: (2020)

(E)-1-(2,4,6-Trihydroxybenzylidene)-4-ethylthiosemicarbazide dihydrate
por: Shawish, Hana Bashir, et al.
Publicado: (2010)

(E)-2-(Benzyliminomethyl)-4,6-dibromophenol
por: Jiang, Wei
Publicado: (2008)

Excellent Catalytic Performances of a Au/C–CuO Binary System in the Selective Oxidation of Benzylamines to Imines under Atmospheric Oxygen
por: Yamamoto, Yuki, et al.
Publicado: (2021)

2,4,6-Trifluoroaniline
por: Betz, Richard, et al.
Publicado: (2008)

2,4,6-Triphenylaniline
por: Ugono, Onome, et al.
Publicado: (2010)

Atom-efficient synthesis of 2,4,6-trisubstituted 1,3,5-triazines via Fe-catalyzed cyclization of aldehydes with NH(4)I as the sole nitrogen source
por: Xiao, Jiang, et al.
Publicado: (2020)

Novel and Simple Method for Quantification of 2,4,6-Trichlorophenol with Microbial Conversion to 2,4,6-Trichloroanisole
por: Goto, Saki, et al.
Publicado: (2023)

(E,E)-1,2-Bis(2,4,6-trimethoxybenzylidene)hydrazine
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

(E)-2-Methoxy-N′-(2,4,6-trihydroxybenzylidene)benzohydrazide
por: Taha, Muhammad, et al.
Publicado: (2013)

Metal-Free Synthesis of 2-Substituted Quinazolines via Green Oxidation of o-Aminobenzylamines: Practical Construction of N-Containing Heterocycles Based on a Salicylic Acid-Catalyzed Oxidation System
por: Yamamoto, Yuki, et al.
Publicado: (2022)

N,N′-Bis[(E)-2,4,6-trimethylbenzylidene]ethane-1,2-diamine
por: Yumata, Nonzaliseko, et al.
Publicado: (2011)

2,4,6-Trimethylanilinium bromide
por: Cui, Li-Jing, et al.
Publicado: (2009)

Morpholinium 2,4,6-trinitrophenolate
por: Vembu, Nagarajan, et al.
Publicado: (2008)

2,4,6-Trimethylpyridinium nitrate
por: Sharif, Shahzad, et al.
Publicado: (2010)

2,4,6-Trifluorobenzoic acid
por: Betz, Richard, et al.
Publicado: (2011)

2,4,6-Trinitrophenyl benzoate
por: Moreno-Fuquen, Rodolfo, et al.
Publicado: (2012)

Crystal structures of 2,4,6-triiodobenzonitrile and 2,4,6-triiodophenyl isocyanide
por: Noland, Wayland E., et al.
Publicado: (2018)

4,6-Bis[4-(benzylsulfanyl)styryl]-2-(methylsulfanyl)pyrimidine
por: Wang, Min, et al.
Publicado: (2007)

5-(4-Fluorobenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
por: Zeng, Wu-Lan
Publicado: (2010)

1-[2,4,6-Trimethyl-3,5-bis(4-oxopiperidin-1-ylmethyl)benzyl]piperidin-4-one
por: Rajesh, K., et al.
Publicado: (2010)

Bis(2-benzyliminomethyl-4,6-dihydroselenophenolato)iron(II)
por: Li, Hai-Yan, et al.
Publicado: (2009)

Synthesis, molecular docking, and in silico ADMET studies of 4-benzyl-1-(2,4,6-trimethyl-benzyl)-piperidine: Potential Inhibitor of SARS-CoV2
por: Nandini Asha, R., et al.
Publicado: (2021)

5-(3,4-Dimethoxybenzylidene)-1,3-dimethyl-1,3-diazinane-2,4,6-trione
por: Gohain, Mukut, et al.
Publicado: (2011)

2,4,6-Trinitrophenyl 4-chlorobenzoate
por: Moreno-Fuquen, Rodolfo, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_dprbtbmklhtuqjocq24veqd5pn