Cargando…

Synthesis and Neuroprotective Properties of N-Substituted C-Dialkoxyphosphorylated Nitrones

[Image: see text] Herein, we report the synthesis and neuroprotective power of some N-substituted C-(dialkoxy)phosphorylated nitrones 4a–g, by studying their ability to increase the cell viability, as well as their capacity to reduce necrosis and apoptosis. We have identified (Z)-N-tert-butyl-1-(die...

Descripción completa

Detalles Bibliográficos
Autores principales:	Piotrowska, Dorota G., Mediavilla, Laura, Cuarental, Leticia, Głowacka, Iwona E., Marco-Contelles, José, Hadjipavlou-Litina, Dimitra, López-Muñoz, Francisco, Oset-Gasque, María Jesús
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648307/ https://www.ncbi.nlm.nih.gov/pubmed/31459948 http://dx.doi.org/10.1021/acsomega.9b00189

Ejemplares similares

Nucleobase-Derived Nitrones: Synthesis and Antioxidant and Neuroprotective Activities in an In Vitro Model of Ischemia–Reperfusion
por: Chamorro, Beatriz, et al.
Publicado: (2022)

Synthesis and Antioxidant Properties of Novel 1,2,3-Triazole-Containing Nitrones
por: Hadjipavlou-Litina, Dimitra, et al.
Publicado: (2022)

Homo-Tris-Nitrones Derived from α-Phenyl-N-tert-butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties
por: Diez-Iriepa, Daniel, et al.
Publicado: (2020)

Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models
por: Chamorro, Beatriz, et al.
Publicado: (2020)

Synthesis and Antioxidant Properties of HeteroBisNitrones Derived from Benzene Dicarbaldehydes
por: Diez-Iriepa, Daniel, et al.
Publicado: (2022)

Neuroprotective and Antioxidant Properties of CholesteroNitrone ChN2 and QuinolylNitrone QN23 in an Experimental Model of Cerebral Ischemia: Involvement of Necrotic and Apoptotic Cell Death
por: Chamorro, Beatriz, et al.
Publicado: (2023)

Synthesis, Neuroprotection, and Antioxidant Activity of 1,1′-Biphenylnitrones as α-Phenyl-N-tert-butylnitrone Analogues in In Vitro Ischemia Models
por: Chamorro, Beatriz, et al.
Publicado: (2021)

Neuroprotective and antioxidant properties of new quinolylnitrones in in vitro and in vivo cerebral ischemia models
por: Chamorro, Beatriz, et al.
Publicado: (2023)

Melatonin and Nitrones As Potential Therapeutic Agents for Stroke
por: Romero, Alejandro, et al.
Publicado: (2016)

Corrigendum: Melatonin and Nitrones As Potential Therapeutic Agents for Stroke
por: Romero, Alejandro, et al.
Publicado: (2017)

Polyfunctionalized α-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment
por: Diez-Iriepa, Daniel, et al.
Publicado: (2022)

Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges
por: Varela-Nieto, Isabel, et al.
Publicado: (2021)

Neuroprotection by Phytoestrogens in the Model of Deprivation and Resupply of Oxygen and Glucose In Vitro: The Contribution of Autophagy and Related Signaling Mechanisms
por: Abbruzzese, Giuseppe, et al.
Publicado: (2020)

Para-Substituted α-Phenyl-N-tert-butyl Nitrones: Spin-Trapping, Redox and Neuroprotective Properties
por: Deletraz, Anaïs, et al.
Publicado: (2020)

Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies
por: Pontiki, Eleni, et al.
Publicado: (2018)

Novel 6- and 7-Substituted Coumarins with Inhibitory Action against Lipoxygenase and Tumor-Associated Carbonic Anhydrase IX
por: Peperidou, Aikaterini, et al.
Publicado: (2018)

Synthesis and Pharmacochemistry of New Pleiotropic Pyrrolyl Derivatives
por: Konstantinidou, Markella, et al.
Publicado: (2015)

Reactivities of Substituted α-Phenyl-N-tert-butyl Nitrones
por: Rosselin, Marie, et al.
Publicado: (2014)

Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy
por: Zhang, Zaijun, et al.
Publicado: (2016)

Curcumin in Health and Diseases: Alzheimer’s Disease and Curcumin Analogues, Derivatives, and Hybrids
por: Chainoglou, Eirini, et al.
Publicado: (2020)

Comparison of Substituting Ability of Nitronate versus Enolate for Direct Substitution of a Nitro Group
por: Mukaijo, Yusuke, et al.
Publicado: (2020)

Hybrids as NO Donors
por: Tsopka, Ioanna-Chrysoula, et al.
Publicado: (2021)

Novel Cinnamic Acid Derivatives as Antioxidant and Anticancer Agents: Design, Synthesis and Modeling Studies
por: Pontiki, Eleni, et al.
Publicado: (2014)

2-Arylidene-1-indandiones as Pleiotropic Agents with Antioxidant and Inhibitory Enzymes Activities †
por: Kouzi, Olympia, et al.
Publicado: (2019)

Pyrazoles and Pyrazolines as Anti-Inflammatory Agents
por: Mantzanidou, Martha, et al.
Publicado: (2021)

The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity
por: Rajić, Zrinka, et al.
Publicado: (2010)

Boronic Acid Group: A Cumbersome False Negative Case in the Process of Drug Design
por: Katsamakas, Sotirios, et al.
Publicado: (2016)

Synthesis of Enantiomerically Enriched Protected 2-Amino-, 2,3-Diamino- and 2-Amino-3-Hydroxypropylphosphonates
por: Trocha, Aleksandra, et al.
Publicado: (2023)

Synthesis of Enantiomerically Pure N-Boc-Protected 1,2,3-Triaminopropylphosphonates and 1,2-Diamino-3-Hydroxypropylphosphonates
por: Trocha, Aleksandra, et al.
Publicado: (2019)

Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker
por: Piotrowska, Dorota G., et al.
Publicado: (2012)

Synthesis of Functionalized Diethyl(pyrrolidin-2-yl)phosphonate and Diethyl(5-oxopyrrolidin-2-yl)phosphonate
por: Głowacka, Iwona E., et al.
Publicado: (2021)

Organosilicon-Containing Thiazole Derivatives as Potential Lipoxygenase Inhibitors and Anti-Inflammatory Agents
por: Geronikaki, Athina, et al.
Publicado: (2007)

The Occurrence of Flavonoids and Related Compounds in Cedrus brevifolia A. Henry ex Elwes & A. Henry Needles. Inhibitory Potencies on Lipoxygenase, Linoleic Acid Lipid Peroxidation and Antioxidant Activity
por: Douros, Andreas, et al.
Publicado: (2017)

Multitarget Molecular Hybrids of Cinnamic Acids
por: Peperidou, Aikaterini, et al.
Publicado: (2014)

5-(4H)-Oxazolones and Their Benzamides as Potential Bioactive Small Molecules
por: Mavridis, Evangelos, et al.
Publicado: (2020)

Hybridization of Curcumin Analogues with Cinnamic Acid Derivatives as Multi-Target Agents Against Alzheimer’s Disease Targets
por: Chainoglou, Eirini, et al.
Publicado: (2020)

Synthesis of Four Enantiomers of (1-Amino-3-Hydroxypropane-1,3-Diyl)Diphosphonic Acid as Diphosphonate Analogues of 4-Hydroxyglutamic Acid
por: Lebelt, Liwia, et al.
Publicado: (2022)

Characterization of a CholesteroNitrone (ISQ-201), a Novel Drug Candidate for the Treatment of Ischemic Stroke
por: Martínez-Alonso, Emma, et al.
Publicado: (2020)

Synthesis of nonracemic hydroxyglutamic acids
por: Piotrowska, Dorota G, et al.
Publicado: (2019)

Simple electrochemical reduction of nitrones to amines
por: Rodrigo, Eduardo, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9131gqeue73lrg594afq0v9h36