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Biochemical reconstitution of UV-induced mutational processes

We reconstituted two biochemical processes that may contribute to UV-induced mutagenesis in vitro and analysed the mutational profiles in the products. One process is translesion synthesis (TLS) by DNA polymerases (Pol) δ, η and ζ, which creates C>T transitions at pyrimidine dimers by incorporati...

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Detalles Bibliográficos
Autores principales:	Sugiyama, Tomohiko, Chen, Yizhang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648339/ https://www.ncbi.nlm.nih.gov/pubmed/31053851 http://dx.doi.org/10.1093/nar/gkz335

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