RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease

Stabilization of stalled replication forks prevents excessive fork reversal or degradation, which can undermine genome integrity. The WRN protein is unique among the other human RecQ family members to possess exonuclease activity. However, the biological role of the WRN exonuclease is poorly defined...

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Detalles Bibliográficos
Autores principales: Aiello, Francesca Antonella, Palma, Anita, Malacaria, Eva, Zheng, Li, Campbell, Judith L, Shen, Binghui, Franchitto, Annapaola, Pichierri, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648349/
https://www.ncbi.nlm.nih.gov/pubmed/31114910
http://dx.doi.org/10.1093/nar/gkz431

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