Sequence Tolerance of a Single-Domain Antibody with a High Thermal Stability: Comparison of Computational and Experimental Fitness Profiles

[Image: see text] The sequence fitness of a llama single-domain antibody with an unusually high thermal stability is explored by a combined computational and experimental study. Starting with the X-ray crystallographic structure, RosettaBackrub simulations were applied to model sequence–structure to...

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Detalles Bibliográficos
Autores principales: Olson, Mark A., Legler, Patricia M., Zabetakis, Daniel, Turner, Kendrick B., Anderson, George P., Goldman, Ellen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648363/
https://www.ncbi.nlm.nih.gov/pubmed/31460140
http://dx.doi.org/10.1021/acsomega.9b00730

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