Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K-10 Clay Explored as Protection–Deprotection Chemistry

[Image: see text] An interesting synthetic transformation of protection–deprotection chemistry in an isatin molecule is achieved. Morita–Baylis–Hillman (MBH) adduct formation used as protection of the C-3 position in the isatin molecule is reported. C–C bond cleavage in the MBH adduct of isatin with...

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Autores principales: Vadivel, Vaithiyanathan, Ganesan, Ravichandran, Kannaiyan, Vishnu, Vellikannu, Ezhumalai, Vijayakumar, Thirumailavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648401/
https://www.ncbi.nlm.nih.gov/pubmed/31460047
http://dx.doi.org/10.1021/acsomega.9b01002
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author Vadivel, Vaithiyanathan
Ganesan, Ravichandran
Kannaiyan, Vishnu
Vellikannu, Ezhumalai
Vijayakumar, Thirumailavan
author_facet Vadivel, Vaithiyanathan
Ganesan, Ravichandran
Kannaiyan, Vishnu
Vellikannu, Ezhumalai
Vijayakumar, Thirumailavan
author_sort Vadivel, Vaithiyanathan
collection PubMed
description [Image: see text] An interesting synthetic transformation of protection–deprotection chemistry in an isatin molecule is achieved. Morita–Baylis–Hillman (MBH) adduct formation used as protection of the C-3 position in the isatin molecule is reported. C–C bond cleavage in the MBH adduct of isatin with the help of phenylhydrazine and C=N bond cleavage in the phenylhydrazone derivative of isatin with the help of K10 clay are studied systematically and reported as deprotection.
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spelling pubmed-66484012019-08-27 Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K-10 Clay Explored as Protection–Deprotection Chemistry Vadivel, Vaithiyanathan Ganesan, Ravichandran Kannaiyan, Vishnu Vellikannu, Ezhumalai Vijayakumar, Thirumailavan ACS Omega [Image: see text] An interesting synthetic transformation of protection–deprotection chemistry in an isatin molecule is achieved. Morita–Baylis–Hillman (MBH) adduct formation used as protection of the C-3 position in the isatin molecule is reported. C–C bond cleavage in the MBH adduct of isatin with the help of phenylhydrazine and C=N bond cleavage in the phenylhydrazone derivative of isatin with the help of K10 clay are studied systematically and reported as deprotection. American Chemical Society 2019-05-31 /pmc/articles/PMC6648401/ /pubmed/31460047 http://dx.doi.org/10.1021/acsomega.9b01002 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Vadivel, Vaithiyanathan
Ganesan, Ravichandran
Kannaiyan, Vishnu
Vellikannu, Ezhumalai
Vijayakumar, Thirumailavan
Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K-10 Clay Explored as Protection–Deprotection Chemistry
title Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K-10 Clay Explored as Protection–Deprotection Chemistry
title_full Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K-10 Clay Explored as Protection–Deprotection Chemistry
title_fullStr Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K-10 Clay Explored as Protection–Deprotection Chemistry
title_full_unstemmed Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K-10 Clay Explored as Protection–Deprotection Chemistry
title_short Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K-10 Clay Explored as Protection–Deprotection Chemistry
title_sort synthesis of substituted isatins from the mbh adduct of 1,5,6-trisubstituted isatins using (2,4-dinitrophenyl)hydrazine and k-10 clay explored as protection–deprotection chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648401/
https://www.ncbi.nlm.nih.gov/pubmed/31460047
http://dx.doi.org/10.1021/acsomega.9b01002
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