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Synthesis and CYP24A1-Dependent Metabolism of 23-Fluorinated Vitamin D(3) Analogues
[Image: see text] Two novel 23-fluorinated 25-hydroxyvitamin D(3) analogues were synthesized using Inhoffen–Lythgoe diol as a precursor of the CD-ring, efficiently. Introduction of the C23 fluoro group was achieved by the deoxy-fluorination reaction using N,N-diethylaminosulfur trifluoride or 2-pyri...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648426/ https://www.ncbi.nlm.nih.gov/pubmed/31460236 http://dx.doi.org/10.1021/acsomega.9b01500 |