Three-Component Cascade Reaction of 1,1-Enediamines, N,N-Dimethylformamide Dimethyl Acetal, and 1,3-Dicarbonyl Compounds: Selective Synthesis of Diverse 2-Aminopyridine Derivatives

[Image: see text] A novel approach has been developed for the synthesis of three kinds of highly functionalized 2-aminopyridine derivatives (APDs) through a three-component reaction of 1,1-enediamines (EDAMs) 1, N,N-dimethylformamide dimethyl acetal (DMF-DMA) 2, and 1,3-dicarbonyl compounds 3–5 via...

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Autores principales: Zi, Quan-Xing, Yan, Sheng-Jiao, Yang, Chang-Long, Li, Kun, Lin, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648487/
https://www.ncbi.nlm.nih.gov/pubmed/31459516
http://dx.doi.org/10.1021/acsomega.8b03284
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author Zi, Quan-Xing
Yan, Sheng-Jiao
Yang, Chang-Long
Li, Kun
Lin, Jun
author_facet Zi, Quan-Xing
Yan, Sheng-Jiao
Yang, Chang-Long
Li, Kun
Lin, Jun
author_sort Zi, Quan-Xing
collection PubMed
description [Image: see text] A novel approach has been developed for the synthesis of three kinds of highly functionalized 2-aminopyridine derivatives (APDs) through a three-component reaction of 1,1-enediamines (EDAMs) 1, N,N-dimethylformamide dimethyl acetal (DMF-DMA) 2, and 1,3-dicarbonyl compounds 3–5 via a base-promoted cascade reaction, producing the desired products in good to excellent yields. This method represents a route to obtain a novel class of APDs in a concise, rapid, and practical manner. This approach is particularly attractive because of the following features: low cost, mild temperature, atom economy, high yields, and potential biological activity of the product.
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spelling pubmed-66484872019-08-27 Three-Component Cascade Reaction of 1,1-Enediamines, N,N-Dimethylformamide Dimethyl Acetal, and 1,3-Dicarbonyl Compounds: Selective Synthesis of Diverse 2-Aminopyridine Derivatives Zi, Quan-Xing Yan, Sheng-Jiao Yang, Chang-Long Li, Kun Lin, Jun ACS Omega [Image: see text] A novel approach has been developed for the synthesis of three kinds of highly functionalized 2-aminopyridine derivatives (APDs) through a three-component reaction of 1,1-enediamines (EDAMs) 1, N,N-dimethylformamide dimethyl acetal (DMF-DMA) 2, and 1,3-dicarbonyl compounds 3–5 via a base-promoted cascade reaction, producing the desired products in good to excellent yields. This method represents a route to obtain a novel class of APDs in a concise, rapid, and practical manner. This approach is particularly attractive because of the following features: low cost, mild temperature, atom economy, high yields, and potential biological activity of the product. American Chemical Society 2019-02-07 /pmc/articles/PMC6648487/ /pubmed/31459516 http://dx.doi.org/10.1021/acsomega.8b03284 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Zi, Quan-Xing
Yan, Sheng-Jiao
Yang, Chang-Long
Li, Kun
Lin, Jun
Three-Component Cascade Reaction of 1,1-Enediamines, N,N-Dimethylformamide Dimethyl Acetal, and 1,3-Dicarbonyl Compounds: Selective Synthesis of Diverse 2-Aminopyridine Derivatives
title Three-Component Cascade Reaction of 1,1-Enediamines, N,N-Dimethylformamide Dimethyl Acetal, and 1,3-Dicarbonyl Compounds: Selective Synthesis of Diverse 2-Aminopyridine Derivatives
title_full Three-Component Cascade Reaction of 1,1-Enediamines, N,N-Dimethylformamide Dimethyl Acetal, and 1,3-Dicarbonyl Compounds: Selective Synthesis of Diverse 2-Aminopyridine Derivatives
title_fullStr Three-Component Cascade Reaction of 1,1-Enediamines, N,N-Dimethylformamide Dimethyl Acetal, and 1,3-Dicarbonyl Compounds: Selective Synthesis of Diverse 2-Aminopyridine Derivatives
title_full_unstemmed Three-Component Cascade Reaction of 1,1-Enediamines, N,N-Dimethylformamide Dimethyl Acetal, and 1,3-Dicarbonyl Compounds: Selective Synthesis of Diverse 2-Aminopyridine Derivatives
title_short Three-Component Cascade Reaction of 1,1-Enediamines, N,N-Dimethylformamide Dimethyl Acetal, and 1,3-Dicarbonyl Compounds: Selective Synthesis of Diverse 2-Aminopyridine Derivatives
title_sort three-component cascade reaction of 1,1-enediamines, n,n-dimethylformamide dimethyl acetal, and 1,3-dicarbonyl compounds: selective synthesis of diverse 2-aminopyridine derivatives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648487/
https://www.ncbi.nlm.nih.gov/pubmed/31459516
http://dx.doi.org/10.1021/acsomega.8b03284
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