Titanium Tetraiodide/Trimethylsilyl Iodide Synergistically Induced Cyclization of N-(2-Cyanophenyl)benzamides into 2-Aryl-4-iodoquinazolines

[Image: see text] Synthesis of 2-aryl-4-iodoquinazolines is developed using titanium tetraiodide/trimethylsilyl iodide synergistically induced cyclization of N-(2-cyanophenyl)benzamides. The cyclization reactions proceeded to give the 2-aryl-4-iodoquinazolines in moderate to high yields. Remarkable...

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Autores principales: Hachiya, Iwao, Nagoshi, Shintaro, Shimizu, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648542/
https://www.ncbi.nlm.nih.gov/pubmed/31460142
http://dx.doi.org/10.1021/acsomega.9b01199
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author Hachiya, Iwao
Nagoshi, Shintaro
Shimizu, Makoto
author_facet Hachiya, Iwao
Nagoshi, Shintaro
Shimizu, Makoto
author_sort Hachiya, Iwao
collection PubMed
description [Image: see text] Synthesis of 2-aryl-4-iodoquinazolines is developed using titanium tetraiodide/trimethylsilyl iodide synergistically induced cyclization of N-(2-cyanophenyl)benzamides. The cyclization reactions proceeded to give the 2-aryl-4-iodoquinazolines in moderate to high yields. Remarkable synergetic effect of titanium tetraiodide and trimethylsilyl iodide was observed to promote the cyclization. The method was applied to the formal synthesis of a potent analgesic agent.
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spelling pubmed-66485422019-08-27 Titanium Tetraiodide/Trimethylsilyl Iodide Synergistically Induced Cyclization of N-(2-Cyanophenyl)benzamides into 2-Aryl-4-iodoquinazolines Hachiya, Iwao Nagoshi, Shintaro Shimizu, Makoto ACS Omega [Image: see text] Synthesis of 2-aryl-4-iodoquinazolines is developed using titanium tetraiodide/trimethylsilyl iodide synergistically induced cyclization of N-(2-cyanophenyl)benzamides. The cyclization reactions proceeded to give the 2-aryl-4-iodoquinazolines in moderate to high yields. Remarkable synergetic effect of titanium tetraiodide and trimethylsilyl iodide was observed to promote the cyclization. The method was applied to the formal synthesis of a potent analgesic agent. American Chemical Society 2019-06-17 /pmc/articles/PMC6648542/ /pubmed/31460142 http://dx.doi.org/10.1021/acsomega.9b01199 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Hachiya, Iwao
Nagoshi, Shintaro
Shimizu, Makoto
Titanium Tetraiodide/Trimethylsilyl Iodide Synergistically Induced Cyclization of N-(2-Cyanophenyl)benzamides into 2-Aryl-4-iodoquinazolines
title Titanium Tetraiodide/Trimethylsilyl Iodide Synergistically Induced Cyclization of N-(2-Cyanophenyl)benzamides into 2-Aryl-4-iodoquinazolines
title_full Titanium Tetraiodide/Trimethylsilyl Iodide Synergistically Induced Cyclization of N-(2-Cyanophenyl)benzamides into 2-Aryl-4-iodoquinazolines
title_fullStr Titanium Tetraiodide/Trimethylsilyl Iodide Synergistically Induced Cyclization of N-(2-Cyanophenyl)benzamides into 2-Aryl-4-iodoquinazolines
title_full_unstemmed Titanium Tetraiodide/Trimethylsilyl Iodide Synergistically Induced Cyclization of N-(2-Cyanophenyl)benzamides into 2-Aryl-4-iodoquinazolines
title_short Titanium Tetraiodide/Trimethylsilyl Iodide Synergistically Induced Cyclization of N-(2-Cyanophenyl)benzamides into 2-Aryl-4-iodoquinazolines
title_sort titanium tetraiodide/trimethylsilyl iodide synergistically induced cyclization of n-(2-cyanophenyl)benzamides into 2-aryl-4-iodoquinazolines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648542/
https://www.ncbi.nlm.nih.gov/pubmed/31460142
http://dx.doi.org/10.1021/acsomega.9b01199
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AT nagoshishintaro titaniumtetraiodidetrimethylsilyliodidesynergisticallyinducedcyclizationofn2cyanophenylbenzamidesinto2aryl4iodoquinazolines
AT shimizumakoto titaniumtetraiodidetrimethylsilyliodidesynergisticallyinducedcyclizationofn2cyanophenylbenzamidesinto2aryl4iodoquinazolines

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