Environmentally Benign, Base-Promoted Selective Amination of Polyhalogenated Pyridines

[Image: see text] An environmentally benign, highly efficient, and base-promoted selective amination of various polyhalogenated pyridines including the challenging pyridine chlorides to 2-aminopyridine derivatives using water as solvent has been developed. Featuring the use of the new method, the re...

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Autores principales: Sun, Chao, Yao, Wubing, Chen, Xu, Zhao, Yiwen, Wei, Qiqi, Chen, Zishuang, Wu, Jiashou, Hao, Feiyue, Xie, Huiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648585/
https://www.ncbi.nlm.nih.gov/pubmed/31460151
http://dx.doi.org/10.1021/acsomega.9b01031
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author Sun, Chao
Yao, Wubing
Chen, Xu
Zhao, Yiwen
Wei, Qiqi
Chen, Zishuang
Wu, Jiashou
Hao, Feiyue
Xie, Huiping
author_facet Sun, Chao
Yao, Wubing
Chen, Xu
Zhao, Yiwen
Wei, Qiqi
Chen, Zishuang
Wu, Jiashou
Hao, Feiyue
Xie, Huiping
author_sort Sun, Chao
collection PubMed
description [Image: see text] An environmentally benign, highly efficient, and base-promoted selective amination of various polyhalogenated pyridines including the challenging pyridine chlorides to 2-aminopyridine derivatives using water as solvent has been developed. Featuring the use of the new method, the reaction is extended to the transformation on a large scale. Mechanistic studies indicate that the pathway involving a base aidant dissociation of N,N-dimethylformamide to generate dimethylamine is likely.
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spelling pubmed-66485852019-08-27 Environmentally Benign, Base-Promoted Selective Amination of Polyhalogenated Pyridines Sun, Chao Yao, Wubing Chen, Xu Zhao, Yiwen Wei, Qiqi Chen, Zishuang Wu, Jiashou Hao, Feiyue Xie, Huiping ACS Omega [Image: see text] An environmentally benign, highly efficient, and base-promoted selective amination of various polyhalogenated pyridines including the challenging pyridine chlorides to 2-aminopyridine derivatives using water as solvent has been developed. Featuring the use of the new method, the reaction is extended to the transformation on a large scale. Mechanistic studies indicate that the pathway involving a base aidant dissociation of N,N-dimethylformamide to generate dimethylamine is likely. American Chemical Society 2019-06-18 /pmc/articles/PMC6648585/ /pubmed/31460151 http://dx.doi.org/10.1021/acsomega.9b01031 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Sun, Chao
Yao, Wubing
Chen, Xu
Zhao, Yiwen
Wei, Qiqi
Chen, Zishuang
Wu, Jiashou
Hao, Feiyue
Xie, Huiping
Environmentally Benign, Base-Promoted Selective Amination of Polyhalogenated Pyridines
title Environmentally Benign, Base-Promoted Selective Amination of Polyhalogenated Pyridines
title_full Environmentally Benign, Base-Promoted Selective Amination of Polyhalogenated Pyridines
title_fullStr Environmentally Benign, Base-Promoted Selective Amination of Polyhalogenated Pyridines
title_full_unstemmed Environmentally Benign, Base-Promoted Selective Amination of Polyhalogenated Pyridines
title_short Environmentally Benign, Base-Promoted Selective Amination of Polyhalogenated Pyridines
title_sort environmentally benign, base-promoted selective amination of polyhalogenated pyridines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648585/
https://www.ncbi.nlm.nih.gov/pubmed/31460151
http://dx.doi.org/10.1021/acsomega.9b01031
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