Metabolic factors that affect health-related quality of life in type 2 diabetes patients: a multivariate regression analysis

PURPOSE: In the past few decades, an increase in the life span of the population has caused more people to experience chronic diseases, such as type 2 diabetes. Since chronic diseases influence the whole life of patients and do not have a specific remedy, improving their health-related quality of life (HRQoL) becomes more important. The aim of the present study was to investigate the metabolic variables that influenced HRQoL questionnaire scores most significantly among patients with type 2 diabetes. PATIENTS AND METHODS: The population of this cross-sectional study included 163 patients with type 2 diabetes and 214 healthy people who were asked to complete the HRQoL questionnaire, and their metabolic blood variables were recorded simultaneously. The effects of metabolic variables and some other demographic ones on two main scales of HRQoL, Mental Component Summary (MCS) and Physical Component Summary (PCS), were evaluated using multivariate regression. RESULTS: Multivariate regression analysis showed that PCS score was most negatively influenced by cigarette smoking (P=0.009, β-15.761), maximum blood pressure (P=0.008, β=−0.108), minimum blood pressure (P=0.009, β=−0.039), low-density lipoprotein cholesterol (P=0.008, β=−0.721), cholesterol (P=0.006, β=−0.648), HbA1c (P=0.004, β=–0.878), FBS (p=0.006, β=−0.769), and body mass index (BMI) (P=0.034, β=–0.287). The MCS score was influenced positively by smoking cigarettes (P=0.041, β=13.032), gender (P=0.018, β=15.633), and BMI (P=0.048, β=−0.088). Men had a higher MCS score compared to women. CONCLUSION: The HRQoL questionnaire (as a concept of health) score could be improved by controlling the variation of some metabolic variables in patients with type 2 diabetes. Some metabolic variables could be the main causes of a decrease in physical and mental HRQoL among patients with type 2 diabetes.