Three-Step Telescoped Synthesis of Monosubstituted Vicinal Diamines from Aldehydes

[Image: see text] Aldehydes are easily transformed into vicinal diamines and piperazines through a one-pot procedure including a Darzens reaction and treatment with an amine or diamine and then with a reducing agent. Additionally, quinoxalines can be accessed by reaction with 1,2-benzenediamine unde...

Descripción completa

Detalles Bibliográficos
Autores principales: Bou-Iserte, Lledó, Latorre, Antonio, Rodríguez, Santiago, González, Florenci V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648690/
https://www.ncbi.nlm.nih.gov/pubmed/31459468
http://dx.doi.org/10.1021/acsomega.8b03030
_version_ 1783437923313516544
author Bou-Iserte, Lledó
Latorre, Antonio
Rodríguez, Santiago
González, Florenci V.
author_facet Bou-Iserte, Lledó
Latorre, Antonio
Rodríguez, Santiago
González, Florenci V.
author_sort Bou-Iserte, Lledó
collection PubMed
description [Image: see text] Aldehydes are easily transformed into vicinal diamines and piperazines through a one-pot procedure including a Darzens reaction and treatment with an amine or diamine and then with a reducing agent. Additionally, quinoxalines can be accessed by reaction with 1,2-benzenediamine under oxidative conditions. These transformations are simple methods for the preparation of synthetically interesting monosubstituted diamines, piperazines, and quinoxalines.
format Online
Article
Text
id pubmed-6648690
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-66486902019-08-27 Three-Step Telescoped Synthesis of Monosubstituted Vicinal Diamines from Aldehydes Bou-Iserte, Lledó Latorre, Antonio Rodríguez, Santiago González, Florenci V. ACS Omega [Image: see text] Aldehydes are easily transformed into vicinal diamines and piperazines through a one-pot procedure including a Darzens reaction and treatment with an amine or diamine and then with a reducing agent. Additionally, quinoxalines can be accessed by reaction with 1,2-benzenediamine under oxidative conditions. These transformations are simple methods for the preparation of synthetically interesting monosubstituted diamines, piperazines, and quinoxalines. American Chemical Society 2019-01-29 /pmc/articles/PMC6648690/ /pubmed/31459468 http://dx.doi.org/10.1021/acsomega.8b03030 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Bou-Iserte, Lledó
Latorre, Antonio
Rodríguez, Santiago
González, Florenci V.
Three-Step Telescoped Synthesis of Monosubstituted Vicinal Diamines from Aldehydes
title Three-Step Telescoped Synthesis of Monosubstituted Vicinal Diamines from Aldehydes
title_full Three-Step Telescoped Synthesis of Monosubstituted Vicinal Diamines from Aldehydes
title_fullStr Three-Step Telescoped Synthesis of Monosubstituted Vicinal Diamines from Aldehydes
title_full_unstemmed Three-Step Telescoped Synthesis of Monosubstituted Vicinal Diamines from Aldehydes
title_short Three-Step Telescoped Synthesis of Monosubstituted Vicinal Diamines from Aldehydes
title_sort three-step telescoped synthesis of monosubstituted vicinal diamines from aldehydes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648690/
https://www.ncbi.nlm.nih.gov/pubmed/31459468
http://dx.doi.org/10.1021/acsomega.8b03030
work_keys_str_mv AT bouisertelledo threesteptelescopedsynthesisofmonosubstitutedvicinaldiaminesfromaldehydes
AT latorreantonio threesteptelescopedsynthesisofmonosubstitutedvicinaldiaminesfromaldehydes
AT rodriguezsantiago threesteptelescopedsynthesisofmonosubstitutedvicinaldiaminesfromaldehydes
AT gonzalezflorenciv threesteptelescopedsynthesisofmonosubstitutedvicinaldiaminesfromaldehydes

Ejemplares similares