Iodine-Mediated Oxidative Rearrangement of α,β-Unsaturated Diaryl Ketones: A Facile Access to 1,2-Diaryl Diketones

[Image: see text] A metal-free oxidative rearrangement was explored for the synthesis of 1,2-diaryl diketones by utilizing α,β-unsaturated diaryl ketones and I(2)/TBHP in good to high yields. The reaction proceeds via oxidative aryl migration, followed by C–C bond cleavage. A simple and high-yieldin...

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Autores principales: Bansode, Ajay H., Suryavanshi, Gurunath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648810/
https://www.ncbi.nlm.nih.gov/pubmed/31460054
http://dx.doi.org/10.1021/acsomega.9b00833
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author Bansode, Ajay H.
Suryavanshi, Gurunath
author_facet Bansode, Ajay H.
Suryavanshi, Gurunath
author_sort Bansode, Ajay H.
collection PubMed
description [Image: see text] A metal-free oxidative rearrangement was explored for the synthesis of 1,2-diaryl diketones by utilizing α,β-unsaturated diaryl ketones and I(2)/TBHP in good to high yields. The reaction proceeds via oxidative aryl migration, followed by C–C bond cleavage. A simple and high-yielding protocol was developed for the synthesis of a wide range of 1,2-diaryl diketones, which are the backbone for a variety of medicinally important molecules.
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spelling pubmed-66488102019-08-27 Iodine-Mediated Oxidative Rearrangement of α,β-Unsaturated Diaryl Ketones: A Facile Access to 1,2-Diaryl Diketones Bansode, Ajay H. Suryavanshi, Gurunath ACS Omega [Image: see text] A metal-free oxidative rearrangement was explored for the synthesis of 1,2-diaryl diketones by utilizing α,β-unsaturated diaryl ketones and I(2)/TBHP in good to high yields. The reaction proceeds via oxidative aryl migration, followed by C–C bond cleavage. A simple and high-yielding protocol was developed for the synthesis of a wide range of 1,2-diaryl diketones, which are the backbone for a variety of medicinally important molecules. American Chemical Society 2019-06-04 /pmc/articles/PMC6648810/ /pubmed/31460054 http://dx.doi.org/10.1021/acsomega.9b00833 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Bansode, Ajay H.
Suryavanshi, Gurunath
Iodine-Mediated Oxidative Rearrangement of α,β-Unsaturated Diaryl Ketones: A Facile Access to 1,2-Diaryl Diketones
title Iodine-Mediated Oxidative Rearrangement of α,β-Unsaturated Diaryl Ketones: A Facile Access to 1,2-Diaryl Diketones
title_full Iodine-Mediated Oxidative Rearrangement of α,β-Unsaturated Diaryl Ketones: A Facile Access to 1,2-Diaryl Diketones
title_fullStr Iodine-Mediated Oxidative Rearrangement of α,β-Unsaturated Diaryl Ketones: A Facile Access to 1,2-Diaryl Diketones
title_full_unstemmed Iodine-Mediated Oxidative Rearrangement of α,β-Unsaturated Diaryl Ketones: A Facile Access to 1,2-Diaryl Diketones
title_short Iodine-Mediated Oxidative Rearrangement of α,β-Unsaturated Diaryl Ketones: A Facile Access to 1,2-Diaryl Diketones
title_sort iodine-mediated oxidative rearrangement of α,β-unsaturated diaryl ketones: a facile access to 1,2-diaryl diketones
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648810/
https://www.ncbi.nlm.nih.gov/pubmed/31460054
http://dx.doi.org/10.1021/acsomega.9b00833
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AT suryavanshigurunath iodinemediatedoxidativerearrangementofabunsaturateddiarylketonesafacileaccessto12diaryldiketones

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