Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues

[Image: see text] The worldwide use of the broad-spectrum antimicrobial trimethoprim (TMP) has induced the rise of TMP-resistant microorganisms. In addition to resistance-causing mutations of the microbial chromosomal dihydrofolate reductase (Dfr), the evolutionarily and structurally unrelated type...

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Detalles Bibliográficos
Autores principales: Toulouse, Jacynthe L., Yachnin, Brahm J., Ruediger, Edward H., Deon, Daniel, Gagnon, Marc, Saint-Jacques, Kévin, Ebert, Maximilian C. C. J. C., Forge, Delphine, Bastien, Dominic, Colin, Damien Y., Vanden Eynde, Jean Jacques, Marinier, Anne, Berghuis, Albert M., Pelletier, Joelle N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648814/
https://www.ncbi.nlm.nih.gov/pubmed/31460098
http://dx.doi.org/10.1021/acsomega.9b00640

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