Synthesis and Biological Activities of Aplyronine A Analogues toward the Development of Antitumor Protein–Protein Interaction Inducers between Actin and Tubulin: Conjugation of the C1–C9 Macrolactone Part and the C24–C34 Side Chain

[Image: see text] Aplyronine A (ApA) is an antitumor marine macrolide that induces an protein–protein interaction (PPI) between actin and tubulin. The C1–C9 macrolactone part including the C7 N,N,O-trimethylserine (TMSer) ester is important for its highly potent activities. To develop new antitumor...

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Detalles Bibliográficos
Autores principales: Futaki, Kentaro, Takahashi, Momoko, Tanabe, Kenta, Fujieda, Akari, Kigoshi, Hideo, Kita, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648920/
https://www.ncbi.nlm.nih.gov/pubmed/31459949
http://dx.doi.org/10.1021/acsomega.9b01099

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