Regio- and Enantioselective (Het)arylation of β-Alkenyl Pyrroline to α-Aryl-β-alkenyl Pyrrolidines

[Image: see text] Regio- and enantioselective direct arylation of β-alkenyl pyrroline is reported. A wide range of electron-rich arenes and heteroarenes reacted under mild conditions with different β-alkenyl pyrrolines to provide structurally diverse α-aryl-β-alkenyl pyrrolidines with very good yiel...

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Autores principales: Dwari, Soumita, Jana, Chandan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649053/
https://www.ncbi.nlm.nih.gov/pubmed/31459483
http://dx.doi.org/10.1021/acsomega.8b03033
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author Dwari, Soumita
Jana, Chandan K.
author_facet Dwari, Soumita
Jana, Chandan K.
author_sort Dwari, Soumita
collection PubMed
description [Image: see text] Regio- and enantioselective direct arylation of β-alkenyl pyrroline is reported. A wide range of electron-rich arenes and heteroarenes reacted under mild conditions with different β-alkenyl pyrrolines to provide structurally diverse α-aryl-β-alkenyl pyrrolidines with very good yields and excellent regioselectivity. Enantioselective reaction in the presence of Lewis acids and chiral phosphoric acids provided the desired arylated product with 73% enantiomeric excess.
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spelling pubmed-66490532019-08-27 Regio- and Enantioselective (Het)arylation of β-Alkenyl Pyrroline to α-Aryl-β-alkenyl Pyrrolidines Dwari, Soumita Jana, Chandan K. ACS Omega [Image: see text] Regio- and enantioselective direct arylation of β-alkenyl pyrroline is reported. A wide range of electron-rich arenes and heteroarenes reacted under mild conditions with different β-alkenyl pyrrolines to provide structurally diverse α-aryl-β-alkenyl pyrrolidines with very good yields and excellent regioselectivity. Enantioselective reaction in the presence of Lewis acids and chiral phosphoric acids provided the desired arylated product with 73% enantiomeric excess. American Chemical Society 2019-01-31 /pmc/articles/PMC6649053/ /pubmed/31459483 http://dx.doi.org/10.1021/acsomega.8b03033 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Dwari, Soumita
Jana, Chandan K.
Regio- and Enantioselective (Het)arylation of β-Alkenyl Pyrroline to α-Aryl-β-alkenyl Pyrrolidines
title Regio- and Enantioselective (Het)arylation of β-Alkenyl Pyrroline to α-Aryl-β-alkenyl Pyrrolidines
title_full Regio- and Enantioselective (Het)arylation of β-Alkenyl Pyrroline to α-Aryl-β-alkenyl Pyrrolidines
title_fullStr Regio- and Enantioselective (Het)arylation of β-Alkenyl Pyrroline to α-Aryl-β-alkenyl Pyrrolidines
title_full_unstemmed Regio- and Enantioselective (Het)arylation of β-Alkenyl Pyrroline to α-Aryl-β-alkenyl Pyrrolidines
title_short Regio- and Enantioselective (Het)arylation of β-Alkenyl Pyrroline to α-Aryl-β-alkenyl Pyrrolidines
title_sort regio- and enantioselective (het)arylation of β-alkenyl pyrroline to α-aryl-β-alkenyl pyrrolidines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649053/
https://www.ncbi.nlm.nih.gov/pubmed/31459483
http://dx.doi.org/10.1021/acsomega.8b03033
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