Mitochondria-Targeted New Blue Light-Emitting Fluorescent Molecular Probe

[Image: see text] Discovery of a nontoxic fluorescent molecular probe to “light up” specific cellular organelles is extremely essential to understand dynamics of intracellular components. Here, we report a new nontoxic mitochondria-targeted linear bithiazole compound, containing trifluoroacetyl term...

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Detalles Bibliográficos
Autores principales: Mohapatra, Saswat, Das, Gaurav, Kar, Chirantan, Nitani, Masashi, Ie, Yutaka, Aso, Yoshio, Ghosh, Surajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649077/
https://www.ncbi.nlm.nih.gov/pubmed/31460025
http://dx.doi.org/10.1021/acsomega.8b03331
Descripción
Sumario:[Image: see text] Discovery of a nontoxic fluorescent molecular probe to “light up” specific cellular organelles is extremely essential to understand dynamics of intracellular components. Here, we report a new nontoxic mitochondria-targeted linear bithiazole compound, containing trifluoroacetyl terminal groups, which emits intense blue fluorescence and stained mitochondria of various cells. Interestingly, the power of fluorescence is completely off when the bithiazole unit is stapled by a carbonyl bridge.

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