Mitochondria-Targeted New Blue Light-Emitting Fluorescent Molecular Probe

[Image: see text] Discovery of a nontoxic fluorescent molecular probe to “light up” specific cellular organelles is extremely essential to understand dynamics of intracellular components. Here, we report a new nontoxic mitochondria-targeted linear bithiazole compound, containing trifluoroacetyl term...

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Autores principales: Mohapatra, Saswat, Das, Gaurav, Kar, Chirantan, Nitani, Masashi, Ie, Yutaka, Aso, Yoshio, Ghosh, Surajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649077/
https://www.ncbi.nlm.nih.gov/pubmed/31460025
http://dx.doi.org/10.1021/acsomega.8b03331
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author Mohapatra, Saswat
Das, Gaurav
Kar, Chirantan
Nitani, Masashi
Ie, Yutaka
Aso, Yoshio
Ghosh, Surajit
author_facet Mohapatra, Saswat
Das, Gaurav
Kar, Chirantan
Nitani, Masashi
Ie, Yutaka
Aso, Yoshio
Ghosh, Surajit
author_sort Mohapatra, Saswat
collection PubMed
description [Image: see text] Discovery of a nontoxic fluorescent molecular probe to “light up” specific cellular organelles is extremely essential to understand dynamics of intracellular components. Here, we report a new nontoxic mitochondria-targeted linear bithiazole compound, containing trifluoroacetyl terminal groups, which emits intense blue fluorescence and stained mitochondria of various cells. Interestingly, the power of fluorescence is completely off when the bithiazole unit is stapled by a carbonyl bridge.
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spelling pubmed-66490772019-08-27 Mitochondria-Targeted New Blue Light-Emitting Fluorescent Molecular Probe Mohapatra, Saswat Das, Gaurav Kar, Chirantan Nitani, Masashi Ie, Yutaka Aso, Yoshio Ghosh, Surajit ACS Omega [Image: see text] Discovery of a nontoxic fluorescent molecular probe to “light up” specific cellular organelles is extremely essential to understand dynamics of intracellular components. Here, we report a new nontoxic mitochondria-targeted linear bithiazole compound, containing trifluoroacetyl terminal groups, which emits intense blue fluorescence and stained mitochondria of various cells. Interestingly, the power of fluorescence is completely off when the bithiazole unit is stapled by a carbonyl bridge. American Chemical Society 2019-05-29 /pmc/articles/PMC6649077/ /pubmed/31460025 http://dx.doi.org/10.1021/acsomega.8b03331 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Mohapatra, Saswat
Das, Gaurav
Kar, Chirantan
Nitani, Masashi
Ie, Yutaka
Aso, Yoshio
Ghosh, Surajit
Mitochondria-Targeted New Blue Light-Emitting Fluorescent Molecular Probe
title Mitochondria-Targeted New Blue Light-Emitting Fluorescent Molecular Probe
title_full Mitochondria-Targeted New Blue Light-Emitting Fluorescent Molecular Probe
title_fullStr Mitochondria-Targeted New Blue Light-Emitting Fluorescent Molecular Probe
title_full_unstemmed Mitochondria-Targeted New Blue Light-Emitting Fluorescent Molecular Probe
title_short Mitochondria-Targeted New Blue Light-Emitting Fluorescent Molecular Probe
title_sort mitochondria-targeted new blue light-emitting fluorescent molecular probe
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649077/
https://www.ncbi.nlm.nih.gov/pubmed/31460025
http://dx.doi.org/10.1021/acsomega.8b03331
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AT ieyutaka mitochondriatargetednewbluelightemittingfluorescentmolecularprobe
AT asoyoshio mitochondriatargetednewbluelightemittingfluorescentmolecularprobe
AT ghoshsurajit mitochondriatargetednewbluelightemittingfluorescentmolecularprobe

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