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Mitochondria-Targeted New Blue Light-Emitting Fluorescent Molecular Probe
[Image: see text] Discovery of a nontoxic fluorescent molecular probe to “light up” specific cellular organelles is extremely essential to understand dynamics of intracellular components. Here, we report a new nontoxic mitochondria-targeted linear bithiazole compound, containing trifluoroacetyl term...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649077/ https://www.ncbi.nlm.nih.gov/pubmed/31460025 http://dx.doi.org/10.1021/acsomega.8b03331 |
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author | Mohapatra, Saswat Das, Gaurav Kar, Chirantan Nitani, Masashi Ie, Yutaka Aso, Yoshio Ghosh, Surajit |
author_facet | Mohapatra, Saswat Das, Gaurav Kar, Chirantan Nitani, Masashi Ie, Yutaka Aso, Yoshio Ghosh, Surajit |
author_sort | Mohapatra, Saswat |
collection | PubMed |
description | [Image: see text] Discovery of a nontoxic fluorescent molecular probe to “light up” specific cellular organelles is extremely essential to understand dynamics of intracellular components. Here, we report a new nontoxic mitochondria-targeted linear bithiazole compound, containing trifluoroacetyl terminal groups, which emits intense blue fluorescence and stained mitochondria of various cells. Interestingly, the power of fluorescence is completely off when the bithiazole unit is stapled by a carbonyl bridge. |
format | Online Article Text |
id | pubmed-6649077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-66490772019-08-27 Mitochondria-Targeted New Blue Light-Emitting Fluorescent Molecular Probe Mohapatra, Saswat Das, Gaurav Kar, Chirantan Nitani, Masashi Ie, Yutaka Aso, Yoshio Ghosh, Surajit ACS Omega [Image: see text] Discovery of a nontoxic fluorescent molecular probe to “light up” specific cellular organelles is extremely essential to understand dynamics of intracellular components. Here, we report a new nontoxic mitochondria-targeted linear bithiazole compound, containing trifluoroacetyl terminal groups, which emits intense blue fluorescence and stained mitochondria of various cells. Interestingly, the power of fluorescence is completely off when the bithiazole unit is stapled by a carbonyl bridge. American Chemical Society 2019-05-29 /pmc/articles/PMC6649077/ /pubmed/31460025 http://dx.doi.org/10.1021/acsomega.8b03331 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Mohapatra, Saswat Das, Gaurav Kar, Chirantan Nitani, Masashi Ie, Yutaka Aso, Yoshio Ghosh, Surajit Mitochondria-Targeted New Blue Light-Emitting Fluorescent Molecular Probe |
title | Mitochondria-Targeted New Blue Light-Emitting Fluorescent
Molecular Probe |
title_full | Mitochondria-Targeted New Blue Light-Emitting Fluorescent
Molecular Probe |
title_fullStr | Mitochondria-Targeted New Blue Light-Emitting Fluorescent
Molecular Probe |
title_full_unstemmed | Mitochondria-Targeted New Blue Light-Emitting Fluorescent
Molecular Probe |
title_short | Mitochondria-Targeted New Blue Light-Emitting Fluorescent
Molecular Probe |
title_sort | mitochondria-targeted new blue light-emitting fluorescent
molecular probe |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649077/ https://www.ncbi.nlm.nih.gov/pubmed/31460025 http://dx.doi.org/10.1021/acsomega.8b03331 |
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