Proof of Principle that Molecular Modeling Followed by a Biophysical Experiment Can Develop Small Molecules that Restore Function to the Cardiac Thin Filament in the Presence of Cardiomyopathic Mutations

[Image: see text] This article reports a coupled computational experimental approach to design small molecules aimed at targeting genetic cardiomyopathies. We begin with a fully atomistic model of the cardiac thin filament. To this we dock molecules using accepted computational drug binding methodol...

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Detalles Bibliográficos
Autores principales: Szatkowski, Lukasz, Lynn, Melissa L., Holeman, Teryn, Williams, Michael R., Baldo, Anthony P., Tardiff, Jil C., Schwartz, Steven D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649307/
https://www.ncbi.nlm.nih.gov/pubmed/31342001
http://dx.doi.org/10.1021/acsomega.8b03340

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