(1)H‐(31)P magnetic resonance spectroscopy: effect of biotin in multiple sclerosis

Biotin is thought to improve functional impairment in progressive multiple sclerosis (MS) by upregulating bioenergetic metabolism. We enrolled 19 patients suffering from progressive MS (5 primary and 14 secondary Progressive‐MS). Using cerebral multinuclear magnetic resonance spectroscopy (MMRS) and...

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Detalles Bibliográficos
Autores principales: Guillevin, Carole, Agius, Pierre, Naudin, Mathieu, Herpe, Guillaume, Ragot, Stéphanie, Maubeuge, Nicolas, Philippe Neau, Jean, Guillevin, Rémy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649368/
https://www.ncbi.nlm.nih.gov/pubmed/31353859
http://dx.doi.org/10.1002/acn3.50825
Descripción
Sumario:Biotin is thought to improve functional impairment in progressive multiple sclerosis (MS) by upregulating bioenergetic metabolism. We enrolled 19 patients suffering from progressive MS (5 primary and 14 secondary Progressive‐MS). Using cerebral multinuclear magnetic resonance spectroscopy (MMRS) and clinical evaluation before and after 6 months of biotin cure, we showed significant modifications of: PME/PDE, ATP, and lactate resonances; an improvement of EDSS Neuroscore. Our results are consistent with metabolic pathways concerned with biotin action and could suggest the usefulness of MMRS for monitoring.

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