(1)H‐(31)P magnetic resonance spectroscopy: effect of biotin in multiple sclerosis

Biotin is thought to improve functional impairment in progressive multiple sclerosis (MS) by upregulating bioenergetic metabolism. We enrolled 19 patients suffering from progressive MS (5 primary and 14 secondary Progressive‐MS). Using cerebral multinuclear magnetic resonance spectroscopy (MMRS) and...

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Detalles Bibliográficos
Autores principales: Guillevin, Carole, Agius, Pierre, Naudin, Mathieu, Herpe, Guillaume, Ragot, Stéphanie, Maubeuge, Nicolas, Philippe Neau, Jean, Guillevin, Rémy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649368/
https://www.ncbi.nlm.nih.gov/pubmed/31353859
http://dx.doi.org/10.1002/acn3.50825
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author Guillevin, Carole
Agius, Pierre
Naudin, Mathieu
Herpe, Guillaume
Ragot, Stéphanie
Maubeuge, Nicolas
Philippe Neau, Jean
Guillevin, Rémy
author_facet Guillevin, Carole
Agius, Pierre
Naudin, Mathieu
Herpe, Guillaume
Ragot, Stéphanie
Maubeuge, Nicolas
Philippe Neau, Jean
Guillevin, Rémy
author_sort Guillevin, Carole
collection PubMed
description Biotin is thought to improve functional impairment in progressive multiple sclerosis (MS) by upregulating bioenergetic metabolism. We enrolled 19 patients suffering from progressive MS (5 primary and 14 secondary Progressive‐MS). Using cerebral multinuclear magnetic resonance spectroscopy (MMRS) and clinical evaluation before and after 6 months of biotin cure, we showed significant modifications of: PME/PDE, ATP, and lactate resonances; an improvement of EDSS Neuroscore. Our results are consistent with metabolic pathways concerned with biotin action and could suggest the usefulness of MMRS for monitoring.
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spelling pubmed-66493682019-07-31 (1)H‐(31)P magnetic resonance spectroscopy: effect of biotin in multiple sclerosis Guillevin, Carole Agius, Pierre Naudin, Mathieu Herpe, Guillaume Ragot, Stéphanie Maubeuge, Nicolas Philippe Neau, Jean Guillevin, Rémy Ann Clin Transl Neurol Brief Communications Biotin is thought to improve functional impairment in progressive multiple sclerosis (MS) by upregulating bioenergetic metabolism. We enrolled 19 patients suffering from progressive MS (5 primary and 14 secondary Progressive‐MS). Using cerebral multinuclear magnetic resonance spectroscopy (MMRS) and clinical evaluation before and after 6 months of biotin cure, we showed significant modifications of: PME/PDE, ATP, and lactate resonances; an improvement of EDSS Neuroscore. Our results are consistent with metabolic pathways concerned with biotin action and could suggest the usefulness of MMRS for monitoring. John Wiley and Sons Inc. 2019-06-27 /pmc/articles/PMC6649368/ /pubmed/31353859 http://dx.doi.org/10.1002/acn3.50825 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Guillevin, Carole
Agius, Pierre
Naudin, Mathieu
Herpe, Guillaume
Ragot, Stéphanie
Maubeuge, Nicolas
Philippe Neau, Jean
Guillevin, Rémy
(1)H‐(31)P magnetic resonance spectroscopy: effect of biotin in multiple sclerosis
title (1)H‐(31)P magnetic resonance spectroscopy: effect of biotin in multiple sclerosis
title_full (1)H‐(31)P magnetic resonance spectroscopy: effect of biotin in multiple sclerosis
title_fullStr (1)H‐(31)P magnetic resonance spectroscopy: effect of biotin in multiple sclerosis
title_full_unstemmed (1)H‐(31)P magnetic resonance spectroscopy: effect of biotin in multiple sclerosis
title_short (1)H‐(31)P magnetic resonance spectroscopy: effect of biotin in multiple sclerosis
title_sort (1)h‐(31)p magnetic resonance spectroscopy: effect of biotin in multiple sclerosis
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649368/
https://www.ncbi.nlm.nih.gov/pubmed/31353859
http://dx.doi.org/10.1002/acn3.50825
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