Dynamic ensemble of HIV-1 RRE stem IIB reveals non-native conformations that disrupt the Rev-binding site

The HIV-1 Rev response element (RRE) RNA element mediates the nuclear export of intron containing viral RNAs by forming an oligomeric complex with the viral protein Rev. Stem IIB and nearby stem II three-way junction nucleate oligomerization through cooperative binding of two Rev molecules. Conforma...

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Detalles Bibliográficos
Autores principales: Chu, Chia-Chieh, Plangger, Raphael, Kreutz, Christoph, Al-Hashimi, Hashim M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649712/
https://www.ncbi.nlm.nih.gov/pubmed/31199872
http://dx.doi.org/10.1093/nar/gkz498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649712/
https://www.ncbi.nlm.nih.gov/pubmed/31199872
http://dx.doi.org/10.1093/nar/gkz498

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