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Effect Sizes Hypothesized and Observed in Contemporary Phase III Trials of Targeted and Immunological Therapies for Advanced Cancer

BACKGROUND: We sought to compare the effect sizes hypothesized in the trial design, observed in the trial results, and considered clinically meaningful by the American Society of Clinical Oncology (ASCO) 2014 recommendations, in phase III trials of targeted and immunological therapies. METHODS: We s...

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Detalles Bibliográficos
Autores principales: Lawrence, Nicola Jane, Roncolato, Felicia, Martin, Andrew, Simes, Robert John, Stockler, Martin R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649714/
https://www.ncbi.nlm.nih.gov/pubmed/31360867
http://dx.doi.org/10.1093/jncics/pky037