Transcriptional supercoiling boosts topoisomerase II-mediated knotting of intracellular DNA

Recent studies have revealed that the DNA cross-inversion mechanism of topoisomerase II (topo II) not only removes DNA supercoils and DNA replication intertwines, but also produces small amounts of DNA knots within the clusters of nucleosomes that conform to eukaryotic chromatin. Here, we examine ho...

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Detalles Bibliográficos
Autores principales: Valdés, Antonio, Coronel, Lucia, Martínez-García, Belén, Segura, Joana, Dyson, Sílvia, Díaz-Ingelmo, Ofelia, Micheletti, Cristian, Roca, Joaquim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649788/
https://www.ncbi.nlm.nih.gov/pubmed/31165864
http://dx.doi.org/10.1093/nar/gkz491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649788/
https://www.ncbi.nlm.nih.gov/pubmed/31165864
http://dx.doi.org/10.1093/nar/gkz491

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