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The Landscape of Somatic Genetic Alterations in Breast Cancers from CHEK2 Germline Mutation Carriers

Pathogenic germline variants in checkpoint kinase 2 (CHEK2), which plays pivotal roles in DNA damage response and cell cycle regulation, confer an increased breast cancer (BC) risk. Here, we investigated the phenotypic and genomic characteristics of 33 BCs from CHEK2 germline mutation carriers (16 h...

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Detalles Bibliográficos
Autores principales:	Mandelker, Diana, Kumar, Rahul, Pei, Xin, Selenica, Pier, Setton, Jeremy, Arunachalam, Sasi, Ceyhan-Birsoy, Ozge, Brown, David N, Norton, Larry, Robson, Mark E, Wen, Hannah Y, Powell, Simon, Riaz, Nadeem, Weigelt, Britta, Reis-Filho, Jorge S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649818/ https://www.ncbi.nlm.nih.gov/pubmed/31360903 http://dx.doi.org/10.1093/jncics/pkz027

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