Germline Pathogenic Variants in Homologous Recombination and DNA Repair Genes in an Asian Cohort of Young-Onset Colorectal Cancer

BACKGROUND: Growing evidence suggests a role for cancer susceptibility genes such as BRCA2 and PALB2 in young-onset colorectal cancers. Using a cohort of young colorectal cancer patients, we sought to identify and provide functional evidence for germline pathogenic variants of DNA repair genes not t...

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Detalles Bibliográficos
Autores principales: Toh, Ming Ren, Chiang, Jian Bang, Chong, Siao Ting, Chan, Sock Hoai, Ishak, Nur Diana Binte, Courtney, Eliza, Lee, Wei Hao, Syed Abdillah Al, Syed Muhammad Fahmy Bin, Carson Allen, John, Lim, Kiat Hon, Davila, Sonia, Tan, Patrick, Lim, Weng Khong, Tan, Iain Bee Huat, Ngeow, Joanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649855/
https://www.ncbi.nlm.nih.gov/pubmed/31360874
http://dx.doi.org/10.1093/jncics/pky054

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