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Scarcity of Recurrent Regulatory Driver Mutations in Colorectal Cancer Revealed by Targeted Deep Sequencing

BACKGROUND: Genetic testing of cancer samples primarily focuses on protein-coding regions, despite most mutations arising in noncoding DNA. Noncoding mutations can be pathogenic if they disrupt gene regulation, but the benefits of assessing promoter mutations in driver genes by panel testing has not...

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Detalles Bibliográficos
Autores principales:	Poulos, Rebecca C, Perera, Dilmi, Packham, Deborah, Shah, Anushi, Janitz, Caroline, Pimanda, John E, Hawkins, Nicholas, Ward, Robyn L, Hesson, Luke B, Wong, Jason W H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649856/ https://www.ncbi.nlm.nih.gov/pubmed/31360895 http://dx.doi.org/10.1093/jncics/pkz012

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