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Defining new clinically derived criteria for high disease activity in non-systemic juvenile idiopathic arthritis: a Finnish multicentre study
OBJECTIVES: To redefine criteria for high disease activity (HDA) in JIA, to establish HDA cut-off values for the 10-joint Juvenile Arthritis Disease Activity Score (JADAS10) and clinical JADAS10 (cJADAS10) and to describe the distribution of patients’ disease activity levels based on the JADAS cut-o...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649930/ https://www.ncbi.nlm.nih.gov/pubmed/31431981 http://dx.doi.org/10.1093/rap/rky044 |
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author | Backström, Maria Tynjälä, Pirjo Aalto, Kristiina Ylijoki, Heikki Putto-Laurila, Anne Grönlund, Minna-Maija Kärki, Johanna Keskitalo, Paula Sard, Sirja Pohjankoski, Heini Hietanen, Maiju Witter, Silke Lehto, Helena Löyttyniemi, Eliisa Vähäsalo, Paula |
author_facet | Backström, Maria Tynjälä, Pirjo Aalto, Kristiina Ylijoki, Heikki Putto-Laurila, Anne Grönlund, Minna-Maija Kärki, Johanna Keskitalo, Paula Sard, Sirja Pohjankoski, Heini Hietanen, Maiju Witter, Silke Lehto, Helena Löyttyniemi, Eliisa Vähäsalo, Paula |
author_sort | Backström, Maria |
collection | PubMed |
description | OBJECTIVES: To redefine criteria for high disease activity (HDA) in JIA, to establish HDA cut-off values for the 10-joint Juvenile Arthritis Disease Activity Score (JADAS10) and clinical JADAS10 (cJADAS10) and to describe the distribution of patients’ disease activity levels based on the JADAS cut-off values in the literature. METHODS: Data on 305 treatment-naïve JIA patients were collected from nine paediatric units treating JIA. The median parameters of the JADAS were proposed to be the clinical criteria for HDA. The cut-off values were assessed by using two receiver operating characteristics curve–based methods. The patients were divided into disease activity levels based on currently used JADAS cut-off values. RESULTS: We proposed new criteria for HDA. At least three of the following criteria must be satisfied in both disease courses: in oligoarthritis, two or more active joints, ESR above normal, physician global assessment (PGA) of disease activity ≥2 and parent/patient global assessment (PtGA) of well-being ≥2; in polyarthritis, six or more active joints, ESR above normal, PGA of overall disease activity ≥4 and PtGA of well-being ≥2. The HDA cut-off values for JADAS10 (cJADAS) were ≥6.7 (6.7) for oligoarticular and ≥15.3 (14.1) for polyarticular disease. The distribution of the disease activity levels based on the JADAS cut-off values in the literature varied markedly based on which cut-offs were used. CONCLUSION: New clinically derived criteria for HDA in JIA and both JADAS and cJADAS cut-off values for HDA were proposed. |
format | Online Article Text |
id | pubmed-6649930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-66499302019-08-20 Defining new clinically derived criteria for high disease activity in non-systemic juvenile idiopathic arthritis: a Finnish multicentre study Backström, Maria Tynjälä, Pirjo Aalto, Kristiina Ylijoki, Heikki Putto-Laurila, Anne Grönlund, Minna-Maija Kärki, Johanna Keskitalo, Paula Sard, Sirja Pohjankoski, Heini Hietanen, Maiju Witter, Silke Lehto, Helena Löyttyniemi, Eliisa Vähäsalo, Paula Rheumatol Adv Pract Concise Report OBJECTIVES: To redefine criteria for high disease activity (HDA) in JIA, to establish HDA cut-off values for the 10-joint Juvenile Arthritis Disease Activity Score (JADAS10) and clinical JADAS10 (cJADAS10) and to describe the distribution of patients’ disease activity levels based on the JADAS cut-off values in the literature. METHODS: Data on 305 treatment-naïve JIA patients were collected from nine paediatric units treating JIA. The median parameters of the JADAS were proposed to be the clinical criteria for HDA. The cut-off values were assessed by using two receiver operating characteristics curve–based methods. The patients were divided into disease activity levels based on currently used JADAS cut-off values. RESULTS: We proposed new criteria for HDA. At least three of the following criteria must be satisfied in both disease courses: in oligoarthritis, two or more active joints, ESR above normal, physician global assessment (PGA) of disease activity ≥2 and parent/patient global assessment (PtGA) of well-being ≥2; in polyarthritis, six or more active joints, ESR above normal, PGA of overall disease activity ≥4 and PtGA of well-being ≥2. The HDA cut-off values for JADAS10 (cJADAS) were ≥6.7 (6.7) for oligoarticular and ≥15.3 (14.1) for polyarticular disease. The distribution of the disease activity levels based on the JADAS cut-off values in the literature varied markedly based on which cut-offs were used. CONCLUSION: New clinically derived criteria for HDA in JIA and both JADAS and cJADAS cut-off values for HDA were proposed. Oxford University Press 2018-10-24 /pmc/articles/PMC6649930/ /pubmed/31431981 http://dx.doi.org/10.1093/rap/rky044 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Rheumatology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Concise Report Backström, Maria Tynjälä, Pirjo Aalto, Kristiina Ylijoki, Heikki Putto-Laurila, Anne Grönlund, Minna-Maija Kärki, Johanna Keskitalo, Paula Sard, Sirja Pohjankoski, Heini Hietanen, Maiju Witter, Silke Lehto, Helena Löyttyniemi, Eliisa Vähäsalo, Paula Defining new clinically derived criteria for high disease activity in non-systemic juvenile idiopathic arthritis: a Finnish multicentre study |
title | Defining new clinically derived criteria for high disease activity in non-systemic juvenile idiopathic arthritis: a Finnish multicentre study |
title_full | Defining new clinically derived criteria for high disease activity in non-systemic juvenile idiopathic arthritis: a Finnish multicentre study |
title_fullStr | Defining new clinically derived criteria for high disease activity in non-systemic juvenile idiopathic arthritis: a Finnish multicentre study |
title_full_unstemmed | Defining new clinically derived criteria for high disease activity in non-systemic juvenile idiopathic arthritis: a Finnish multicentre study |
title_short | Defining new clinically derived criteria for high disease activity in non-systemic juvenile idiopathic arthritis: a Finnish multicentre study |
title_sort | defining new clinically derived criteria for high disease activity in non-systemic juvenile idiopathic arthritis: a finnish multicentre study |
topic | Concise Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649930/ https://www.ncbi.nlm.nih.gov/pubmed/31431981 http://dx.doi.org/10.1093/rap/rky044 |
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