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A meta-analysis of multiple matched aCGH/expression cancer datasets reveals regulatory relationships and pathway enrichment of potential oncogenes

The copy numbers of genes in cancer samples are often highly disrupted and form a natural amplification/deletion experiment encompassing multiple genes. Matched array comparative genomics and transcriptomics datasets from such samples can be used to predict inter-chromosomal gene regulatory relation...

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Detalles Bibliográficos
Autores principales: Newton, Richard, Wernisch, Lorenz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650054/
https://www.ncbi.nlm.nih.gov/pubmed/31335867
http://dx.doi.org/10.1371/journal.pone.0213221

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