Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression

The pathogenesis of Plasmodium falciparum malaria is linked to the variant surface antigen PfEMP1, which mediates tethering of infected erythrocytes to the host endothelium and is encoded by approximately 60 var genes per parasite genome. Repeated episodes of malaria infection result in the gradual...

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Detalles Bibliográficos
Autores principales: Bachmann, Anna, Bruske, Ellen, Krumkamp, Ralf, Turner, Louise, Wichers, J. Stephan, Petter, Michaela, Held, Jana, Duffy, Michael F., Sim, B. Kim Lee, Hoffman, Stephen L., Kremsner, Peter G., Lell, Bertrand, Lavstsen, Thomas, Frank, Matthias, Mordmüller, Benjamin, Tannich, Egbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650087/
https://www.ncbi.nlm.nih.gov/pubmed/31295334
http://dx.doi.org/10.1371/journal.ppat.1007906

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