Systematic discovery of the functional impact of somatic genome alterations in individual tumors through tumor-specific causal inference

Cancer is mainly caused by somatic genome alterations (SGAs). Precision oncology involves identifying and targeting tumor-specific aberrations resulting from causative SGAs. We developed a novel tumor-specific computational framework that finds the likely causative SGAs in an individual tumor and es...

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Detalles Bibliográficos
Autores principales: Cai, Chunhui, Cooper, Gregory F., Lu, Kevin N., Ma, Xiaojun, Xu, Shuping, Zhao, Zhenlong, Chen, Xueer, Xue, Yifan, Lee, Adrian V., Clark, Nathan, Chen, Vicky, Lu, Songjian, Chen, Lujia, Yu, Liyue, Hochheiser, Harry S., Jiang, Xia, Wang, Q. Jane, Lu, Xinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650088/
https://www.ncbi.nlm.nih.gov/pubmed/31276486
http://dx.doi.org/10.1371/journal.pcbi.1007088

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