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Spectrotemporal modulation provides a unifying framework for auditory cortical asymmetries

The principles underlying functional asymmetries in cortex remain debated. For example, it is accepted that speech is processed bilaterally in auditory cortex, but a left hemisphere dominance emerges when the input is interpreted linguistically. The mechanisms, however, are contested: what sound fea...

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Autores principales: Flinker, Adeen, Doyle, Werner K., Mehta, Ashesh D., Devinsky, Orrin, Poeppel, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650286/
https://www.ncbi.nlm.nih.gov/pubmed/30971792
http://dx.doi.org/10.1038/s41562-019-0548-z
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author Flinker, Adeen
Doyle, Werner K.
Mehta, Ashesh D.
Devinsky, Orrin
Poeppel, David
author_facet Flinker, Adeen
Doyle, Werner K.
Mehta, Ashesh D.
Devinsky, Orrin
Poeppel, David
author_sort Flinker, Adeen
collection PubMed
description The principles underlying functional asymmetries in cortex remain debated. For example, it is accepted that speech is processed bilaterally in auditory cortex, but a left hemisphere dominance emerges when the input is interpreted linguistically. The mechanisms, however, are contested: what sound features or processing principles underlie laterality? Recent findings across species (humans, canines, bats) provide converging evidence that spectrotemporal sound features drive asymmetrical responses. Typically, accounts invoke models wherein the hemispheres differ in time-frequency resolution or integration window size. We develop a framework that builds on and unifies prevailing models, using spectrotemporal modulation space. Using signal processing techniques motivated by neural responses, we test this approach employing behavioral and neurophysiological measures. We show how psychophysical judgments align with spectrotemporal modulations and then characterize the neural sensitivities to temporal and spectral modulations. We demonstrate differential contributions from both hemispheres, with a left lateralization for temporal modulations and a weaker right lateralization for spectral modulations. We argue that representations in the modulation domain provide a more mechanistic basis to account for lateralization in auditory cortex.
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spelling pubmed-66502862019-09-04 Spectrotemporal modulation provides a unifying framework for auditory cortical asymmetries Flinker, Adeen Doyle, Werner K. Mehta, Ashesh D. Devinsky, Orrin Poeppel, David Nat Hum Behav Article The principles underlying functional asymmetries in cortex remain debated. For example, it is accepted that speech is processed bilaterally in auditory cortex, but a left hemisphere dominance emerges when the input is interpreted linguistically. The mechanisms, however, are contested: what sound features or processing principles underlie laterality? Recent findings across species (humans, canines, bats) provide converging evidence that spectrotemporal sound features drive asymmetrical responses. Typically, accounts invoke models wherein the hemispheres differ in time-frequency resolution or integration window size. We develop a framework that builds on and unifies prevailing models, using spectrotemporal modulation space. Using signal processing techniques motivated by neural responses, we test this approach employing behavioral and neurophysiological measures. We show how psychophysical judgments align with spectrotemporal modulations and then characterize the neural sensitivities to temporal and spectral modulations. We demonstrate differential contributions from both hemispheres, with a left lateralization for temporal modulations and a weaker right lateralization for spectral modulations. We argue that representations in the modulation domain provide a more mechanistic basis to account for lateralization in auditory cortex. 2019-03-04 2019-04 /pmc/articles/PMC6650286/ /pubmed/30971792 http://dx.doi.org/10.1038/s41562-019-0548-z Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Flinker, Adeen
Doyle, Werner K.
Mehta, Ashesh D.
Devinsky, Orrin
Poeppel, David
Spectrotemporal modulation provides a unifying framework for auditory cortical asymmetries
title Spectrotemporal modulation provides a unifying framework for auditory cortical asymmetries
title_full Spectrotemporal modulation provides a unifying framework for auditory cortical asymmetries
title_fullStr Spectrotemporal modulation provides a unifying framework for auditory cortical asymmetries
title_full_unstemmed Spectrotemporal modulation provides a unifying framework for auditory cortical asymmetries
title_short Spectrotemporal modulation provides a unifying framework for auditory cortical asymmetries
title_sort spectrotemporal modulation provides a unifying framework for auditory cortical asymmetries
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650286/
https://www.ncbi.nlm.nih.gov/pubmed/30971792
http://dx.doi.org/10.1038/s41562-019-0548-z
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