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Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α

Duplication of ancestral hypoxia-inducible factor (HIF)α coincided with the evolution of vertebrate species. Paralogs HIF1α and HIF2α are the most well-known factors for modulating the cellular transcriptional profile following hypoxia. However, how the processes of natural selection acted upon the...

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Detalles Bibliográficos
Autores principales:	Tarade, Daniel, Lee, Jeffrey E., Ohh, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650433/ https://www.ncbi.nlm.nih.gov/pubmed/31337753 http://dx.doi.org/10.1038/s41467-019-11149-1

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