Cargando…

HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules

The combined regulation of a network of inhibitory and activating T cell receptors may be a critical step in the development of chronic HCV infection. Ex vivo HCV MHC class I + II tetramer staining and bead-enrichment was performed with baseline and longitudinal PBMC samples of a cohort of patients...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ackermann, Christin, Smits, Maike, Woost, Robin, Eberhard, Johanna M., Peine, Sven, Kummer, Silke, Marget, Matthias, Kuntzen, Thomas, Kwok, William W., Lohse, Ansgar W., Jacobs, Thomas, Boettler, Tobias, Schulze zur Wiesch, Julian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650447/ https://www.ncbi.nlm.nih.gov/pubmed/31337800 http://dx.doi.org/10.1038/s41598-019-47024-8

Ejemplares similares

Treatment and re-treatment results of HCV patients in the DAA era
por: Piecha, Felix, et al.
Publicado: (2020)

Increased frequency of TIGIT(+)CD73-CD8(+) T cells with a TOX(+) TCF-1low profile in patients with newly diagnosed and relapsed AML
por: Brauneck, F., et al.
Publicado: (2021)

Frequency of IRF5+ dendritic cells is associated with the TLR7-induced inflammatory cytokine response in SARS-CoV-2 infection
por: Cords, Leon, et al.
Publicado: (2023)

HCV-Specific T Cell Responses During and After Chronic HCV Infection
por: Luxenburger, Hendrik, et al.
Publicado: (2018)

High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4(+) T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19
por: Cords, Leon, et al.
Publicado: (2022)

Characterization of the immune cell landscape of patients with NAFLD
por: Diedrich, Tom, et al.
Publicado: (2020)

German cohort of HCV mono-infected and HCV/HIV co-infected patients reveals relative under-treatment of co-infected patients
por: Beisel, Claudia, et al.
Publicado: (2014)

Increased CD56(bright) NK cells in HIV-HCV co-infection and HCV mono-infection are associated with distinctive alterations of their phenotype
por: Bhardwaj, Suvercha, et al.
Publicado: (2016)

Mucosal‐associated invariant T‐cell frequency and function in blood and liver of HCV mono‐ and HCV/HIV co‐infected patients with advanced fibrosis
por: Beudeker, Boris J. B., et al.
Publicado: (2017)

HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis
por: Medvedev, Regina, et al.
Publicado: (2016)

Detection of EXP1-Specific CD4+ T Cell Responses Directed Against a Broad Range of Epitopes Including Two Promiscuous MHC Class II Binders During Acute Plasmodium falciparum Malaria
por: Heide, Janna, et al.
Publicado: (2020)

Analysis of Co-inhibitory Receptor Expression in COVID-19 Infection Compared to Acute Plasmodium falciparum Malaria: LAG-3 and TIM-3 Correlate With T Cell Activation and Course of Disease
por: Herrmann, Marissa, et al.
Publicado: (2020)

The Clinical Perspective on Hepatitis E
por: Horvatits, Thomas, et al.
Publicado: (2019)

Priming persistence of HCV
por: Schuch, Anita, et al.
Publicado: (2015)

CD8 Epitope Escape and Reversion in Acute HCV Infection
por: Timm, Joerg, et al.
Publicado: (2004)

HCV core antigen and HCV-RNA in HIV/HCV co-infected patients with different HCV genotypes
por: Garbuglia, Anna Rosa, et al.
Publicado: (2014)

The correlation of HCV RNA and HCV core antigen in different genotypes of HCV
por: Xiang, Yu, et al.
Publicado: (2018)

HCV and lichen planus: HCV and lichen planus
por: Rebora, Alfredo
Publicado: (2011)

High‐resolution analysis of individual spike peptide‐specific CD4 (+) T‐cell responses in vaccine recipients and COVID‐19 patients
por: Karsten, Hendrik, et al.
Publicado: (2022)

Nonalcoholic fatty liver disease is associated with excessive calorie intake rather than a distinctive dietary pattern
por: Wehmeyer, Malte H., et al.
Publicado: (2016)

Frequent detection of functional hyposplenism via assessment of pitted erythrocytes in patients with advanced liver cirrhosis
por: Wehmeyer, Malte H., et al.
Publicado: (2022)

Effect of combined siRNA of HCV E2 gene and HCV receptors against HCV
por: Jahan, Shah, et al.
Publicado: (2011)

Combined Blockade of TIGIT and CD39 or A2AR Enhances NK-92 Cell-Mediated Cytotoxicity in AML
por: Brauneck, Franziska, et al.
Publicado: (2021)

Significance of Anti-Nuclear Antibodies and Cryoglobulins in Patients with Acute and Chronic HEV Infection
por: Horvatits, Thomas, et al.
Publicado: (2020)

Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis A
por: Brehm, Thomas Theo, et al.
Publicado: (2021)

The Burgeoning HIV/HCV Syndemic in the Urban Northeast: HCV, HIV, and HIV/HCV Coinfection in an Urban Setting
por: Morano, Jamie P., et al.
Publicado: (2013)

Effectiveness of HCV core antigen and RNA quantification in HCV-infected and HCV/HIV-1-coinfected patients
por: Long, Lu, et al.
Publicado: (2014)

HCV core antigen plays an important role in the fight against HCV as an alternative to HCV‐RNA detection
por: Wang, Yuhan, et al.
Publicado: (2021)

HCV resistance
por: Halfon, Philippe
Publicado: (2012)

HCV and Lymphoproliferation
por: Zignego, Anna Linda, et al.
Publicado: (2012)

LncRNAs in HCV Infection and HCV-Related Liver Disease
por: Unfried, Juan P., et al.
Publicado: (2020)

Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19
por: Heide, Janna, et al.
Publicado: (2021)

Correction: Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19
por: Heide, Janna, et al.
Publicado: (2022)

Detection of HCV-Specific IFN-γ Responses in HCV Antibody and HCV RNA Negative Injecting Drug Users
por: Flynn, Jacqueline K, et al.
Publicado: (2014)

Hepatitis C (HCV) therapy for HCV mono-infected and HIV-HCV co-infected individuals living in Nepal
por: KC, Sudhamshu, et al.
Publicado: (2020)

Bone Marrow-Resident Vδ1 T Cells Co-express TIGIT With PD-1, TIM-3 or CD39 in AML and Myeloma
por: Brauneck, Franziska, et al.
Publicado: (2021)

Sofosbuvir plus velpatasvir for 8 weeks in patients with acute hepatitis C: The HepNet acute HCV-V study
por: Maasoumy, Benjamin, et al.
Publicado: (2022)

Hepatitis C virus (HCV) infection and re-infection among HCV- and HIV/HCV-infected injection drug users
por: Conway, B, et al.
Publicado: (2010)

Insights on the Russian HCV care cascade: minimal HCV treatment for HIV/HCV co-infected PWID in St. Petersburg
por: Tsui, Judith I., et al.
Publicado: (2016)

HCV antigen instead of RNA testing to diagnose acute HCV in patients treated in the Dutch Acute HCV in HIV Study
por: Hullegie, Sebastiaan J., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_cdivs885n3ae7lo0vou8bm4h0m