Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

Allosteric modulators are highly desirable as drugs, particularly for G-protein-coupled receptor (GPCR) targets, because allosteric drugs can achieve selectivity between closely related receptors. The mechanisms by which allosteric modulators achieve selectivity remain elusive, however, particularly...

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Detalles Bibliográficos
Autores principales: Hollingsworth, Scott A., Kelly, Brendan, Valant, Celine, Michaelis, Jordan Arthur, Mastromihalis, Olivia, Thompson, Geoff, Venkatakrishnan, A. J., Hertig, Samuel, Scammells, Peter J., Sexton, Patrick M., Felder, Christian C., Christopoulos, Arthur, Dror, Ron O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650467/
https://www.ncbi.nlm.nih.gov/pubmed/31337749
http://dx.doi.org/10.1038/s41467-019-11062-7

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