Production and in vivo PET/CT imaging of the theranostic pair (132/135)La

The present study describes a novel method for the low energy cyclotron production and radiochemical isolation of no-carrier-added (132/135)La(3+) from bulk (nat)Ba. This separation strategy combines precipitation and single-column extraction chromatography to afford an overall radiochemical yield (...

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Detalles Bibliográficos
Autores principales: Aluicio-Sarduy, Eduardo, Hernandez, Reinier, Olson, Aeli P., Barnhart, Todd E., Cai, Weibo, Ellison, Paul A., Engle, Jonathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650468/
https://www.ncbi.nlm.nih.gov/pubmed/31337833
http://dx.doi.org/10.1038/s41598-019-47137-0
Descripción
Sumario:The present study describes a novel method for the low energy cyclotron production and radiochemical isolation of no-carrier-added (132/135)La(3+) from bulk (nat)Ba. This separation strategy combines precipitation and single-column extraction chromatography to afford an overall radiochemical yield (92 ± 2%) and apparent molar activity (22 ± 4 Mbq/nmol) suitable for the radiolabeling of DOTA-conjugated vectors. The produced (132/135)La(3+) has a radiochemical and radionuclidic purity amenable for (132)La/(135)La-based cancer theranostic applications. Longitudinal PET/CT images acquired using the positron-emitting (132)La and ex vivo biodistribution data separately corroborated the accumulation of unchelated (132/135)La(3+) ions in bone and the liver.

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