Production and in vivo PET/CT imaging of the theranostic pair (132/135)La

The present study describes a novel method for the low energy cyclotron production and radiochemical isolation of no-carrier-added (132/135)La(3+) from bulk (nat)Ba. This separation strategy combines precipitation and single-column extraction chromatography to afford an overall radiochemical yield (...

Descripción completa

Detalles Bibliográficos
Autores principales: Aluicio-Sarduy, Eduardo, Hernandez, Reinier, Olson, Aeli P., Barnhart, Todd E., Cai, Weibo, Ellison, Paul A., Engle, Jonathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650468/
https://www.ncbi.nlm.nih.gov/pubmed/31337833
http://dx.doi.org/10.1038/s41598-019-47137-0
_version_ 1783438134149644288
author Aluicio-Sarduy, Eduardo
Hernandez, Reinier
Olson, Aeli P.
Barnhart, Todd E.
Cai, Weibo
Ellison, Paul A.
Engle, Jonathan W.
author_facet Aluicio-Sarduy, Eduardo
Hernandez, Reinier
Olson, Aeli P.
Barnhart, Todd E.
Cai, Weibo
Ellison, Paul A.
Engle, Jonathan W.
author_sort Aluicio-Sarduy, Eduardo
collection PubMed
description The present study describes a novel method for the low energy cyclotron production and radiochemical isolation of no-carrier-added (132/135)La(3+) from bulk (nat)Ba. This separation strategy combines precipitation and single-column extraction chromatography to afford an overall radiochemical yield (92 ± 2%) and apparent molar activity (22 ± 4 Mbq/nmol) suitable for the radiolabeling of DOTA-conjugated vectors. The produced (132/135)La(3+) has a radiochemical and radionuclidic purity amenable for (132)La/(135)La-based cancer theranostic applications. Longitudinal PET/CT images acquired using the positron-emitting (132)La and ex vivo biodistribution data separately corroborated the accumulation of unchelated (132/135)La(3+) ions in bone and the liver.
format Online
Article
Text
id pubmed-6650468
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-66504682019-07-29 Production and in vivo PET/CT imaging of the theranostic pair (132/135)La Aluicio-Sarduy, Eduardo Hernandez, Reinier Olson, Aeli P. Barnhart, Todd E. Cai, Weibo Ellison, Paul A. Engle, Jonathan W. Sci Rep Article The present study describes a novel method for the low energy cyclotron production and radiochemical isolation of no-carrier-added (132/135)La(3+) from bulk (nat)Ba. This separation strategy combines precipitation and single-column extraction chromatography to afford an overall radiochemical yield (92 ± 2%) and apparent molar activity (22 ± 4 Mbq/nmol) suitable for the radiolabeling of DOTA-conjugated vectors. The produced (132/135)La(3+) has a radiochemical and radionuclidic purity amenable for (132)La/(135)La-based cancer theranostic applications. Longitudinal PET/CT images acquired using the positron-emitting (132)La and ex vivo biodistribution data separately corroborated the accumulation of unchelated (132/135)La(3+) ions in bone and the liver. Nature Publishing Group UK 2019-07-23 /pmc/articles/PMC6650468/ /pubmed/31337833 http://dx.doi.org/10.1038/s41598-019-47137-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Aluicio-Sarduy, Eduardo
Hernandez, Reinier
Olson, Aeli P.
Barnhart, Todd E.
Cai, Weibo
Ellison, Paul A.
Engle, Jonathan W.
Production and in vivo PET/CT imaging of the theranostic pair (132/135)La
title Production and in vivo PET/CT imaging of the theranostic pair (132/135)La
title_full Production and in vivo PET/CT imaging of the theranostic pair (132/135)La
title_fullStr Production and in vivo PET/CT imaging of the theranostic pair (132/135)La
title_full_unstemmed Production and in vivo PET/CT imaging of the theranostic pair (132/135)La
title_short Production and in vivo PET/CT imaging of the theranostic pair (132/135)La
title_sort production and in vivo pet/ct imaging of the theranostic pair (132/135)la
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650468/
https://www.ncbi.nlm.nih.gov/pubmed/31337833
http://dx.doi.org/10.1038/s41598-019-47137-0
work_keys_str_mv AT aluiciosarduyeduardo productionandinvivopetctimagingofthetheranosticpair132135la
AT hernandezreinier productionandinvivopetctimagingofthetheranosticpair132135la
AT olsonaelip productionandinvivopetctimagingofthetheranosticpair132135la
AT barnharttodde productionandinvivopetctimagingofthetheranosticpair132135la
AT caiweibo productionandinvivopetctimagingofthetheranosticpair132135la
AT ellisonpaula productionandinvivopetctimagingofthetheranosticpair132135la
AT englejonathanw productionandinvivopetctimagingofthetheranosticpair132135la

Ejemplares similares