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Production and in vivo PET/CT imaging of the theranostic pair (132/135)La
The present study describes a novel method for the low energy cyclotron production and radiochemical isolation of no-carrier-added (132/135)La(3+) from bulk (nat)Ba. This separation strategy combines precipitation and single-column extraction chromatography to afford an overall radiochemical yield (...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650468/ https://www.ncbi.nlm.nih.gov/pubmed/31337833 http://dx.doi.org/10.1038/s41598-019-47137-0 |
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author | Aluicio-Sarduy, Eduardo Hernandez, Reinier Olson, Aeli P. Barnhart, Todd E. Cai, Weibo Ellison, Paul A. Engle, Jonathan W. |
author_facet | Aluicio-Sarduy, Eduardo Hernandez, Reinier Olson, Aeli P. Barnhart, Todd E. Cai, Weibo Ellison, Paul A. Engle, Jonathan W. |
author_sort | Aluicio-Sarduy, Eduardo |
collection | PubMed |
description | The present study describes a novel method for the low energy cyclotron production and radiochemical isolation of no-carrier-added (132/135)La(3+) from bulk (nat)Ba. This separation strategy combines precipitation and single-column extraction chromatography to afford an overall radiochemical yield (92 ± 2%) and apparent molar activity (22 ± 4 Mbq/nmol) suitable for the radiolabeling of DOTA-conjugated vectors. The produced (132/135)La(3+) has a radiochemical and radionuclidic purity amenable for (132)La/(135)La-based cancer theranostic applications. Longitudinal PET/CT images acquired using the positron-emitting (132)La and ex vivo biodistribution data separately corroborated the accumulation of unchelated (132/135)La(3+) ions in bone and the liver. |
format | Online Article Text |
id | pubmed-6650468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-66504682019-07-29 Production and in vivo PET/CT imaging of the theranostic pair (132/135)La Aluicio-Sarduy, Eduardo Hernandez, Reinier Olson, Aeli P. Barnhart, Todd E. Cai, Weibo Ellison, Paul A. Engle, Jonathan W. Sci Rep Article The present study describes a novel method for the low energy cyclotron production and radiochemical isolation of no-carrier-added (132/135)La(3+) from bulk (nat)Ba. This separation strategy combines precipitation and single-column extraction chromatography to afford an overall radiochemical yield (92 ± 2%) and apparent molar activity (22 ± 4 Mbq/nmol) suitable for the radiolabeling of DOTA-conjugated vectors. The produced (132/135)La(3+) has a radiochemical and radionuclidic purity amenable for (132)La/(135)La-based cancer theranostic applications. Longitudinal PET/CT images acquired using the positron-emitting (132)La and ex vivo biodistribution data separately corroborated the accumulation of unchelated (132/135)La(3+) ions in bone and the liver. Nature Publishing Group UK 2019-07-23 /pmc/articles/PMC6650468/ /pubmed/31337833 http://dx.doi.org/10.1038/s41598-019-47137-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Aluicio-Sarduy, Eduardo Hernandez, Reinier Olson, Aeli P. Barnhart, Todd E. Cai, Weibo Ellison, Paul A. Engle, Jonathan W. Production and in vivo PET/CT imaging of the theranostic pair (132/135)La |
title | Production and in vivo PET/CT imaging of the theranostic pair (132/135)La |
title_full | Production and in vivo PET/CT imaging of the theranostic pair (132/135)La |
title_fullStr | Production and in vivo PET/CT imaging of the theranostic pair (132/135)La |
title_full_unstemmed | Production and in vivo PET/CT imaging of the theranostic pair (132/135)La |
title_short | Production and in vivo PET/CT imaging of the theranostic pair (132/135)La |
title_sort | production and in vivo pet/ct imaging of the theranostic pair (132/135)la |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650468/ https://www.ncbi.nlm.nih.gov/pubmed/31337833 http://dx.doi.org/10.1038/s41598-019-47137-0 |
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