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Zolpidem for the Treatment of Dystonia

Background and Purpose: There are recent reports of zolpidem being effective for the treatment of a variety of movement disorders, due to its action on the gamma-aminobutyric acid A receptors in the thalamus, subthalamic nucleus, and globus pallidus, hence facilitating inhibitory pathways in the bas...

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Autores principales: Badillo, Stephanie Patricia J., Jamora, Roland Dominic G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650537/
https://www.ncbi.nlm.nih.gov/pubmed/31379728
http://dx.doi.org/10.3389/fneur.2019.00779
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author Badillo, Stephanie Patricia J.
Jamora, Roland Dominic G.
author_facet Badillo, Stephanie Patricia J.
Jamora, Roland Dominic G.
author_sort Badillo, Stephanie Patricia J.
collection PubMed
description Background and Purpose: There are recent reports of zolpidem being effective for the treatment of a variety of movement disorders, due to its action on the gamma-aminobutyric acid A receptors in the thalamus, subthalamic nucleus, and globus pallidus, hence facilitating inhibitory pathways in the basal ganglia motor loop. Its beneficial effects have been described for Parkinson's disease and other related disorders. The objective of this study was to assess the therapeutic effects of zolpidem for various types of dystonia. Methods: We conducted a literature search using MEDLINE via PubMed, Cochrane Library, EMBASE, Scopus, and Google Scholar. Results: There were no randomized controlled trials. The literature included 6 case reports, 4 case series, and 1 non-randomized, non-controlled interventional trial. Overall, 49 adult participants (range 1–34 participants) with a mean age of 49.5 years were treated. Regardless of the dystonia subtype, a single dose of zolpidem at 10 mg causes improvement of symptoms for a mean duration of 3.4 h until patient returns to baseline. The main adverse effect noted was drowsiness, which was dose-dependent. Conclusion: While the current available literature suggests that zolpidem may be an effective pharmacologic option for treating dystonia, however the quality of evidence remains limited. Larger sample size, methodological consistency, and randomized controlled trials with long-term patient follow-ups are necessary to come up with definitive conclusion.
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spelling pubmed-66505372019-08-02 Zolpidem for the Treatment of Dystonia Badillo, Stephanie Patricia J. Jamora, Roland Dominic G. Front Neurol Neurology Background and Purpose: There are recent reports of zolpidem being effective for the treatment of a variety of movement disorders, due to its action on the gamma-aminobutyric acid A receptors in the thalamus, subthalamic nucleus, and globus pallidus, hence facilitating inhibitory pathways in the basal ganglia motor loop. Its beneficial effects have been described for Parkinson's disease and other related disorders. The objective of this study was to assess the therapeutic effects of zolpidem for various types of dystonia. Methods: We conducted a literature search using MEDLINE via PubMed, Cochrane Library, EMBASE, Scopus, and Google Scholar. Results: There were no randomized controlled trials. The literature included 6 case reports, 4 case series, and 1 non-randomized, non-controlled interventional trial. Overall, 49 adult participants (range 1–34 participants) with a mean age of 49.5 years were treated. Regardless of the dystonia subtype, a single dose of zolpidem at 10 mg causes improvement of symptoms for a mean duration of 3.4 h until patient returns to baseline. The main adverse effect noted was drowsiness, which was dose-dependent. Conclusion: While the current available literature suggests that zolpidem may be an effective pharmacologic option for treating dystonia, however the quality of evidence remains limited. Larger sample size, methodological consistency, and randomized controlled trials with long-term patient follow-ups are necessary to come up with definitive conclusion. Frontiers Media S.A. 2019-07-17 /pmc/articles/PMC6650537/ /pubmed/31379728 http://dx.doi.org/10.3389/fneur.2019.00779 Text en Copyright © 2019 Badillo and Jamora. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Badillo, Stephanie Patricia J.
Jamora, Roland Dominic G.
Zolpidem for the Treatment of Dystonia
title Zolpidem for the Treatment of Dystonia
title_full Zolpidem for the Treatment of Dystonia
title_fullStr Zolpidem for the Treatment of Dystonia
title_full_unstemmed Zolpidem for the Treatment of Dystonia
title_short Zolpidem for the Treatment of Dystonia
title_sort zolpidem for the treatment of dystonia
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650537/
https://www.ncbi.nlm.nih.gov/pubmed/31379728
http://dx.doi.org/10.3389/fneur.2019.00779
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