Lysosomal P-gp-MDR1 Confers Drug Resistance of Brentuximab Vedotin and Its Cytotoxic Payload Monomethyl Auristatin E in Tumor Cells

Antibody-drug conjugates (ADCs) are composed of an antibody linked to cytotoxic anticancer payloads. ADCs recognize tumor-specific cell surface antigens and are internalized into lysosomes where proteolytic enzymes release the cytotoxic payloads. Efflux transporters on plasma membrane that play a si...

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Detalles Bibliográficos
Autores principales: Liu-Kreyche, Peggy, Shen, Hong, Marino, Anthony M., Iyer, Ramaswamy A., Humphreys, W. Griffith, Lai, Yurong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650582/
https://www.ncbi.nlm.nih.gov/pubmed/31379564
http://dx.doi.org/10.3389/fphar.2019.00749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650582/
https://www.ncbi.nlm.nih.gov/pubmed/31379564
http://dx.doi.org/10.3389/fphar.2019.00749

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