Reduced Function and Diversity of T Cell Repertoire and Distinct Clinical Course in Patients With IL7RA Mutation

The alpha subunit of IL-7 receptor (IL7R7α) is critical for the differentiation of T cells, specifically for the development and maintenance of γδT cells. Mutations in IL7RA are associated with Severe Combined Immunodeficiency (SCID). Infants with IL7RA deficiency can be identified through newborn s...

Descripción completa

Detalles Bibliográficos
Autores principales: Lev, Atar, Simon, Amos J., Barel, Ortal, Eyal, Eran, Glick-Saar, Efrat, Nayshool, Omri, Birk, Ohad, Stauber, Tali, Hochberg, Amit, Broides, Arnon, Almashanu, Shlomo, Hendel, Ayal, Lee, Yu Nee, Somech, Raz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650764/
https://www.ncbi.nlm.nih.gov/pubmed/31379863
http://dx.doi.org/10.3389/fimmu.2019.01672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650764/
https://www.ncbi.nlm.nih.gov/pubmed/31379863
http://dx.doi.org/10.3389/fimmu.2019.01672

Ejemplares similares