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The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing

Two-pore domain K(+) (K(2P)) channels generate K(+) leak current, which serves a vital role in controlling and modulating neuronal excitability. This diverse family of K(+) channels exhibit distinct expression and function across neuronal tissues. TWIK-related spinal cord K(+) channel (TRESK) is a K...

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Autores principales: Weir, Greg A., Pettingill, Philippa, Wu, Yukyee, Duggal, Galbha, Ilie, Andrei-Sorin, Akerman, Colin J., Cader, M. Zameel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650782/
https://www.ncbi.nlm.nih.gov/pubmed/31379497
http://dx.doi.org/10.3389/fnmol.2019.00170
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author Weir, Greg A.
Pettingill, Philippa
Wu, Yukyee
Duggal, Galbha
Ilie, Andrei-Sorin
Akerman, Colin J.
Cader, M. Zameel
author_facet Weir, Greg A.
Pettingill, Philippa
Wu, Yukyee
Duggal, Galbha
Ilie, Andrei-Sorin
Akerman, Colin J.
Cader, M. Zameel
author_sort Weir, Greg A.
collection PubMed
description Two-pore domain K(+) (K(2P)) channels generate K(+) leak current, which serves a vital role in controlling and modulating neuronal excitability. This diverse family of K(+) channels exhibit distinct expression and function across neuronal tissues. TWIK-related spinal cord K(+) channel (TRESK) is a K(2P) channel with a particularly enriched role in sensory neurons and in vivo pain pathways. Here, we explored the role of TRESK across molecularly distinct sensory neuron populations and assessed its contribution to different sensory modalities. We found TRESK mRNA only in select populations of C- and A-δ nociceptors, in addition to low threshold D-hair afferents. Neurons from mice in which TRESK has been ablated demonstrated marked hyperexcitability, which was amplified under inflammatory challenge. Detailed behavioral phenotyping of TRESK knockout mice revealed specific deficits in somatosensory processing of noxious and non-noxious stimuli. These results demonstrate novel roles of TRESK in somatosensory processing and offer important information to those wishing to target the channel for therapeutic means.
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spelling pubmed-66507822019-08-02 The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing Weir, Greg A. Pettingill, Philippa Wu, Yukyee Duggal, Galbha Ilie, Andrei-Sorin Akerman, Colin J. Cader, M. Zameel Front Mol Neurosci Neuroscience Two-pore domain K(+) (K(2P)) channels generate K(+) leak current, which serves a vital role in controlling and modulating neuronal excitability. This diverse family of K(+) channels exhibit distinct expression and function across neuronal tissues. TWIK-related spinal cord K(+) channel (TRESK) is a K(2P) channel with a particularly enriched role in sensory neurons and in vivo pain pathways. Here, we explored the role of TRESK across molecularly distinct sensory neuron populations and assessed its contribution to different sensory modalities. We found TRESK mRNA only in select populations of C- and A-δ nociceptors, in addition to low threshold D-hair afferents. Neurons from mice in which TRESK has been ablated demonstrated marked hyperexcitability, which was amplified under inflammatory challenge. Detailed behavioral phenotyping of TRESK knockout mice revealed specific deficits in somatosensory processing of noxious and non-noxious stimuli. These results demonstrate novel roles of TRESK in somatosensory processing and offer important information to those wishing to target the channel for therapeutic means. Frontiers Media S.A. 2019-07-17 /pmc/articles/PMC6650782/ /pubmed/31379497 http://dx.doi.org/10.3389/fnmol.2019.00170 Text en Copyright © 2019 Weir, Pettingill, Wu, Duggal, Ilie, Akerman and Cader. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Weir, Greg A.
Pettingill, Philippa
Wu, Yukyee
Duggal, Galbha
Ilie, Andrei-Sorin
Akerman, Colin J.
Cader, M. Zameel
The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing
title The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing
title_full The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing
title_fullStr The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing
title_full_unstemmed The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing
title_short The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing
title_sort role of tresk in discrete sensory neuron populations and somatosensory processing
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650782/
https://www.ncbi.nlm.nih.gov/pubmed/31379497
http://dx.doi.org/10.3389/fnmol.2019.00170
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