Cargando…

A Comparative Study of the Anticancer Activity and PARP-1 Inhibiting Effect of Benzofuran–Pyrazole Scaffold and Its Nano-Sized Particles in Human Breast Cancer Cells

Breast cancer is considered the most common and deadly cancer among women worldwide. Nanomedicine has become extremely attractive in the field of cancer treatment. Due to the high surface to volume ratio and other unique properties, nanomaterials can be specifically targeted to certain cells and tis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anwar, Manal M., Abd El-Karim, Somaia S., Mahmoud, Ahlam H., Amr, Abd El-Galil E., Al-Omar, Mohamed A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650948/ https://www.ncbi.nlm.nih.gov/pubmed/31261939 http://dx.doi.org/10.3390/molecules24132413

Ejemplares similares

Development of a New Benzofuran–Pyrazole–Pyridine-Based Molecule for the Management of Osteoarthritis
por: Abd El-Karim, Somaia S., et al.
Publicado: (2023)

Kinase Inhibitory Activities and Molecular Docking of a Novel Series of Anticancer Pyrazole Derivatives
por: Nossier, Eman S., et al.
Publicado: (2018)

New Quinoxaline-Based Derivatives as PARP-1 Inhibitors: Design, Synthesis, Antiproliferative, and Computational Studies
por: Syam, Yasmin M., et al.
Publicado: (2022)

Synthesis and 2D-QSAR Study of Active Benzofuran-Based Vasodilators
por: Khalifa, Nagy M., et al.
Publicado: (2017)

Anticancer therapeutic potential of benzofuran scaffolds
por: Abbas, Ashraf A., et al.
Publicado: (2023)

New Benzimidazole-, 1,2,4-Triazole-, and 1,3,5-Triazine-Based Derivatives as Potential EGFR(WT) and EGFR(T790M) Inhibitors: Microwave-Assisted Synthesis, Anticancer Evaluation, and Molecular Docking Study
por: Hashem, Heba E., et al.
Publicado: (2022)

Cytotoxic Effects of Newly Synthesized Heterocyclic Candidates Containing Nicotinonitrile and Pyrazole Moieties on Hepatocellular and Cervical Carcinomas
por: A. El-Sayed, Amira, et al.
Publicado: (2019)

Paper Strip and Ceramic Potentiometric Platforms Modified with Nano-Sized Polyaniline (PANi) for Static and Hydrodynamic Monitoring of Chromium in Industrial Samples
por: Hassan, Saad S. M., et al.
Publicado: (2020)

Discovery of New Coumarin-Based Lead with Potential Anticancer, CDK4 Inhibition and Selective Radiotheranostic Effect: Synthesis, 2D & 3D QSAR, Molecular Dynamics, In Vitro Cytotoxicity, Radioiodination, and Biodistribution Studies
por: Sarhan, Mona O., et al.
Publicado: (2021)

Nano Milk Protein-Mucilage Complexes: Characterization and Anticancer Effect
por: El-Maksoud, Ahmed Ali Abd, et al.
Publicado: (2021)

Novel heterocyclic hybrids of pyrazole targeting dihydrofolate reductase: design, biological evaluation and in silico studies
por: Othman, Ismail M. M., et al.
Publicado: (2020)

Porous Activated Carbon from Lignocellulosic Agricultural Waste for the Removal of Acetampirid Pesticide from Aqueous Solutions
por: Mohammad, Somaia G., et al.
Publicado: (2020)

Synthesis and Antimicrobial Evaluation of a New Series of Heterocyclic Systems Bearing a Benzosuberone Scaffold
por: Abd El-Salam, Osama I., et al.
Publicado: (2015)

Synthesis and biological evaluation of new derivatives of thieno-thiazole and dihydrothiazolo-thiazole scaffolds integrated with a pyrazoline nucleus as anticancer and multi-targeting kinase inhibitors
por: Othman, Ismail M. M., et al.
Publicado: (2021)

A SnO(2)/CeO(2) Nano-Composite Catalyst for Alizarin Dye Removal from Aqueous Solutions
por: Hassan, Saad S. M., et al.
Publicado: (2020)

Design, Synthesis, Anticancer Evaluation and Molecular Modeling of Novel Estrogen Derivatives
por: Amr, Abd El-Galil E., et al.
Publicado: (2019)

Synthesis of Some New Pyridine-2,6-carboxamide-derived Schiff Bases as Potential Antimicrobial Agents
por: Al-Omar, Mohamed A., et al.
Publicado: (2010)

Design, Synthesis and Docking Studies of Novel Macrocyclic Pentapeptides as Anticancer Multi-Targeted Kinase Inhibitors
por: Amr, Abd El-Galil E., et al.
Publicado: (2018)

Synthesis and Biological Activities of Some New (N(α)-Dinicotinoyl)-bis-l-Leucyl Linear and Macrocyclic Peptides
por: Khayyat, Suzan, et al.
Publicado: (2014)

Anticancer Activities of Newly Synthesized Chiral Macrocyclic Heptapeptide Candidates
por: Abo-Ghalia, Mohamed H., et al.
Publicado: (2020)

New quinoxaline compounds as DPP-4 inhibitors and hypoglycemics: design, synthesis, computational and bio-distribution studies
por: Syam, Yasmin M., et al.
Publicado: (2021)

The Importance of the Pyrazole Scaffold in the Design of Protein Kinases Inhibitors as Targeted Anticancer Therapies
por: Nitulescu, George Mihai, et al.
Publicado: (2023)

Design, Synthesis, and Molecular Docking Study of Novel Heterocycles Incorporating 1,3,4-Thiadiazole Moiety as Potential Antimicrobial and Anticancer Agents
por: El-Naggar, Mohamed, et al.
Publicado: (2019)

Fluorinated Benzofuran and Dihydrobenzofuran as Anti-Inflammatory and Potential Anticancer Agents
por: Ayoub, Abeer J., et al.
Publicado: (2023)

Quantitative and Qualitative Analysis of the Anti-Proliferative Potential of the Pyrazole Scaffold in the Design of Anticancer Agents
por: Nitulescu, George Mihai
Publicado: (2022)

Synthesis, Antiproliferative, and Antioxidant Evaluation of 2-Pentylquinazolin-4(3H)-one(thione) Derivatives with DFT Study
por: El-Sayed, Amira A., et al.
Publicado: (2019)

Chiral Pyridine-3,5-bis- (L-phenylalaninyl-L-leucinyl) Schiff Base Peptides as Potential Anticancer Agents: Design, Synthesis, and Molecular Docking Studies Targeting Lactate Dehydrogenase-A
por: Amr, Abd El-Galil E., et al.
Publicado: (2020)

Synthesis of Chiral Macrocyclic or Linear Pyridine Carboxamides from Pyridine-2,6-dicarbonyl Dichloride as Antimicrobial Agents
por: Al-Salahi, Rashad A., et al.
Publicado: (2010)

Synthesis and Bioactivity Assessment of Novel Spiro Pyrazole-Oxindole Congeners Exhibiting Potent and Selective in vitro Anticancer Effects
por: Abo-Salem, Heba M., et al.
Publicado: (2020)

Synthesis of New Macrocyclic Polyamides as Antimicrobial Agent Candidates
por: El-Salam, Osama I. Abd, et al.
Publicado: (2012)

Synthesis of New Derivatives of Benzofuran as Potential Anticancer Agents
por: Napiórkowska, Mariola, et al.
Publicado: (2019)

Novel Pyridothienopyrimidine Derivatives: Design, Synthesis and Biological Evaluation as Antimicrobial and Anticancer Agents
por: Mohi El-Deen, Eman M., et al.
Publicado: (2022)

Synthesis and Characterization of CuFe(2)O(4) Nanoparticles Modified with Polythiophene: Applications to Mercuric Ions Removal
por: H. Kamel, Ayman, et al.
Publicado: (2020)

Synthesis, Spectroscopic, Structural and Molecular Docking Studies of Some New Nano-Sized Ferrocene-Based Imine Chelates as Antimicrobial and Anticancer Agents
por: Khalaf, Mai M., et al.
Publicado: (2022)

Antiproliferative Activity of Some Newly Synthesized Substituted Pyridine Candidates Using 4-(Aaryl)-6-(naphthalen-1-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile as Synthon
por: El-Sayed, Amira A., et al.
Publicado: (2021)

Predictors of dementia after first ischemic stroke
por: El-Sheik, Wafik Mahmoud, et al.
Publicado: (2021)

Nanoparticles of a Pyrazolo-Pyridazine Derivative as Potential EGFR and CDK-2 Inhibitors: Design, Structure Determination, Anticancer Evaluation and In Silico Studies
por: Hashem, Heba E., et al.
Publicado: (2023)

Single-Piece Solid Contact Cu(2+)-Selective Electrodes Based on a Synthesized Macrocyclic Calix[4]arene Derivative as a Neutral Carrier Ionophore
por: E. Amr, Abd El-Galil, et al.
Publicado: (2019)

Solid-State Membrane Sensors Based on Man-Tailored Biomimetic Receptors for Selective Recognition of Isoproturon and Diuron Herbicides
por: Kamel, Ayman H., et al.
Publicado: (2020)

Potentiometric PVC-Membrane-Based Sensor for Dimethylamine Assessment Using A Molecularly Imprinted Polymer as A Sensory Recognition Element
por: S. M. Hassan, Saad, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5ov1ob3d29l00qaq9ekst7ddkp